DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 11950:11956

E3 ligase: FBXW7

DEGRON score: 0.9098

ASA_SCORE: 96.7857

COIL: 0.9481

CONS_SCORE: 0

DSS_SCORE: 0.7277

HELIX: 0.0116

FCONS_SCORE: 0

RIG_SCORE: 0.6254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E11949D	TCGA-BR-8680	STAD	TCGA	MPTPPKT	DEG_SCF_FBW7_1	0.3056
p.E11949D	DO47769	STAD	ICGC	MPTPPKT	DEG_SCF_FBW7_1	0.3056
p.P11964L	TCGA-D9-A4Z3	SKCM	TCGA	MPTPPKT	DEG_SCF_FBW7_1	0.1111
p.P11964L	DO222498	MELA	ICGC	MPTPPKT	DEG_SCF_FBW7_1	0.1111
p.P11964L	DO47555	SKCM	ICGC	MPTPPKT	DEG_SCF_FBW7_1	0.1111
p.G11961R	TCGA-EE-A3JD	SKCM	TCGA	MPTPPKT	DEG_SCF_FBW7_1	0.1944
p.G11961R	DO50299	SKCM	ICGC	MPTPPKT	DEG_SCF_FBW7_1	0.1944
p.T11966S	TCGA-OR-A5LD	ACC	TCGA	MPTPPKT	DEG_SCF_FBW7_1	0.0556
p.T11966S	SIDM01169	Ovarian Carcinoma	GDSC	MPTPPKT	DEG_SCF_FBW7_1	0.0556
p.T11966S	ACH-000885	Ovarian Cancer	CCLE	MPTPPKT	DEG_SCF_FBW7_1	0.0556
p.T11966S	TOV-21G	ovary	COSMIC	MPTPPKT	DEG_SCF_FBW7_1	0.0556
p.I11946M	TCGA-VB-A8QN	DLBC	TCGA	MPTPPKT	DEG_SCF_FBW7_1	0.2222
p.I11946M	DO223730	DLBC	ICGC	MPTPPKT	DEG_SCF_FBW7_1	0.2222
p.G11959E	TCGA-W3-AA1V	SKCM	TCGA	MPTPPKT	DEG_SCF_FBW7_1	0.25
p.G11959E	DO229456	SKCA	ICGC	MPTPPKT	DEG_SCF_FBW7_1	0.25
p.G11959E	DO51276	SKCM	ICGC	MPTPPKT	DEG_SCF_FBW7_1	0.25
p.P11951S	DO233767	GACA	ICGC	MPTPPKT	DEG_SCF_FBW7_1	0.5641
p.P11953T	DO228976	LICA	ICGC	MPTPPKT	DEG_SCF_FBW7_1	0.7031
p.T11942S	DO46893	RECA	ICGC	MPTPPKT	DEG_SCF_FBW7_1	0.1111
p.K11955E	SIDM00438	B-Lymphoblastic Leukemia	GDSC	MPTPPKT	DEG_SCF_FBW7_1	0.591
p.K11955E	ACH-002275	Leukemia	CCLE	MPTPPKT	DEG_SCF_FBW7_1	0.591
p.K11955E	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	MPTPPKT	DEG_SCF_FBW7_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	11950:11956	MPTPPKT	FBXW7	0.9098	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons