DegronMD

Uniprot ID: Q12778

Source protein: Forkhead box protein O1

Source gene: FOXO1

Class: DEG_SCF_FBW7_1

Location: 399:406

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 64.9125

COIL: 0.7741

CONS_SCORE: 0.3806

DSS_SCORE: 0.5568

HELIX: 0.1475

FCONS_SCORE: 0.9732

RIG_SCORE: 0.7347

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S406L	TCGA-90-A4ED	LUSC	TCGA	MQQTPCYS	DEG_SCF_FBW7_1	0.7667
p.S406L	DO45482	LUSC	ICGC	MQQTPCYS	DEG_SCF_FBW7_1	0.7667
p.T402M	TCGA-A5-A1OF	UCEC	TCGA	MQQTPCYS	DEG_SCF_FBW7_1	0.8534
p.T402M	DO42568	UCEC	ICGC	MQQTPCYS	DEG_SCF_FBW7_1	0.8534
p.L414S	TCGA-BT-A2LB	BLCA	TCGA	MQQTPCYS	DEG_SCF_FBW7_1	0.1111
p.L414S	DO44098	BLCA	ICGC	MQQTPCYS	DEG_SCF_FBW7_1	0.1111
p.A408T	TCGA-D1-A0ZO	UCEC	TCGA	MQQTPCYS	DEG_SCF_FBW7_1	0.2778
p.A408T	DO41927	UCEC	ICGC	MQQTPCYS	DEG_SCF_FBW7_1	0.2778
p.A408V	TCGA-E6-A1LX	UCEC	TCGA	MQQTPCYS	DEG_SCF_FBW7_1	0.2778
p.A408V	TCGA-HU-A4GU	STAD	TCGA	MQQTPCYS	DEG_SCF_FBW7_1	0.2778
p.A408V	DO47849	STAD	ICGC	MQQTPCYS	DEG_SCF_FBW7_1	0.2778
p.A408V	DO41020	UCEC	ICGC	MQQTPCYS	DEG_SCF_FBW7_1	0.2778
p.P403S	DO11854	GBM	ICGC	MQQTPCYS	DEG_SCF_FBW7_1	0.6752
p.P410Q	DO229015	LICA	ICGC	MQQTPCYS	DEG_SCF_FBW7_1	0.2222
p.Q392K	DO229029	LICA	ICGC	MQQTPCYS	DEG_SCF_FBW7_1	0.1389
p.P409T	DO229045	LICA	ICGC	MQQTPCYS	DEG_SCF_FBW7_1	0.25
p.P409Q	DO229009	LICA	ICGC	MQQTPCYS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12778	Forkhead box protein O1	DEG_SCF_FBW7_1	399:406	MQQTPCYS	FBXW7	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons