DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MQTPRAS
Uniprot ID:
Q9H3T3
Source protein:
Semaphorin-6B
Source gene:
SEMA6B
Class:
DEG_SCF_FBW7_1
Location:
1:7
E3 ligase:
FBXW7
DEGRON score:
0.6171
ASA_SCORE:
111.7714
COIL:
0.9663
CONS_SCORE:
0.326
DSS_SCORE:
0.8381
HELIX:
0.016
FCONS_SCORE:
0.833
RIG_SCORE:
0.6838
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SEMA6B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MQTPRAS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H3T3
Semaphorin-6B
DEG_SCF_FBW7_1
1:7
MQTPRAS
FBXW7
0.6171
More...