DegronMD

Uniprot ID: Q9H2S9

Source protein: Zinc finger protein Eos

Source gene: IKZF4

Class: DEG_APCC_DBOX_1

Location: 337:345

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9372

ASA_SCORE: 78.2889

COIL: 0.6933

CONS_SCORE: 0.5533

DSS_SCORE: 0.3503

HELIX: 0.0226

FCONS_SCORE: 0.9058

RIG_SCORE: 0.7746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D343Y	TCGA-73-A9RS	LUAD	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	0.6214
p.D343Y	SIDM00332	Breast Carcinoma	GDSC	MRFSLSDLP	DEG_APCC_DBOX_1	0.6214
p.D343Y	MFM-223	breast	COSMIC	MRFSLSDLP	DEG_APCC_DBOX_1	0.6214
p.R338H	TCGA-A5-A0G2	UCEC	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	0.8244
p.R338H	TCGA-CM-5861	COAD	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	0.8244
p.K355N	TCGA-D3-A2JC	SKCM	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	0.1667
p.E354K	TCGA-EE-A2MM	SKCM	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	0.0833
p.G352S	TCGA-FR-A3YO	SKCM	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	0.1389
p.R337C	DO9498	COAD	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	0.8301
p.R337C	DO41331	UCEC	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	0.8301
p.T351M	DO230311	COCA	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	0.1667
p.G332V	DO229018	LICA	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	0.1944
p.R337L	DO231104	LUSC	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	0.8428
p.I347M	DO30180	OV	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	0.2778
p.L350P	DO38679	STAD	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	0.1944
p.T351R	ACH-000790	Lung Cancer	CCLE	MRFSLSDLP	DEG_APCC_DBOX_1	0.1667
p.T351R	SHP-77	lung	COSMIC	MRFSLSDLP	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2S9	Zinc finger protein Eos	DEG_APCC_DBOX_1	337:345	MRFSLSDLP	APC,CDC20,FZR1	0.9372	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons