DegronMD

Uniprot ID: O60343

Source protein: TBC1 domain family member 4

Source gene: TBC1D4

Class: DEG_APCC_DBOX_1

Location: 582:590

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9826

ASA_SCORE: 81.6111

COIL: 0.7238

CONS_SCORE: 0.2679

DSS_SCORE: 0.4888

HELIX: 0.1104

FCONS_SCORE: 0.8312

RIG_SCORE: 0.6783

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R577K	TCGA-A5-A2K5	UCEC	TCGA	MRGRLGSVD	DEG_APCC_DBOX_1	0.1944
p.R585W	TCGA-AP-A1DV	UCEC	TCGA	MRGRLGSVD	DEG_APCC_DBOX_1	0.7523
p.R585W	DO43186	UCEC	ICGC	MRGRLGSVD	DEG_APCC_DBOX_1	0.7523
p.R594W	TCGA-CG-5723	STAD	TCGA	MRGRLGSVD	DEG_APCC_DBOX_1	0.2222
p.R594W	DO38376	STAD	ICGC	MRGRLGSVD	DEG_APCC_DBOX_1	0.2222
p.R577M	TCGA-D3-A2JC	SKCM	TCGA	MRGRLGSVD	DEG_APCC_DBOX_1	0.1944
p.F575L	TCGA-DU-6392	LGG	TCGA	MRGRLGSVD	DEG_APCC_DBOX_1	0.1389
p.F575L	DO22237	LGG	ICGC	MRGRLGSVD	DEG_APCC_DBOX_1	0.1389
p.F575L	SIDM01611	Endometrial Carcinoma	GDSC	MRGRLGSVD	DEG_APCC_DBOX_1	0.1389
p.F575L	ACH-000996	Endometrial/Uterine Cancer	CCLE	MRGRLGSVD	DEG_APCC_DBOX_1	0.1389
p.L598I	DO228985	LICA	ICGC	MRGRLGSVD	DEG_APCC_DBOX_1	0.1111
p.L586I	DO229026	LICA	ICGC	MRGRLGSVD	DEG_APCC_DBOX_1	0.7174
p.N596K	DO229036	LICA	ICGC	MRGRLGSVD	DEG_APCC_DBOX_1	0.1667
p.R585Q	DO228138	PBCA	ICGC	MRGRLGSVD	DEG_APCC_DBOX_1	0.6218
p.R585G	DO233487	PRAD	ICGC	MRGRLGSVD	DEG_APCC_DBOX_1	0.6457
p.S597R	ACH-001389	Breast Cancer	CCLE	MRGRLGSVD	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_APCC_DBOX_1	582:590	MRGRLGSVD	APC,CDC20,FZR1	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons