DegronMD

Uniprot ID: Q8IY17

Source protein: Patatin-like phospholipase domain-containing protein 6

Source gene: PNPLA6

Class: DEG_APCC_DBOX_1

Location: 135:143

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6251

ASA_SCORE: 82.0778

COIL: 0.0553

CONS_SCORE: 0.2831

DSS_SCORE: 0.5024

HELIX: 0.941

FCONS_SCORE: 1.0621

RIG_SCORE: 0.8046

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K140E	TCGA-AP-A1DK	UCEC	TCGA	MRKKLKMLN	DEG_APCC_DBOX_1	0.591
p.R150H	TCGA-B5-A3FC	UCEC	TCGA	MRKKLKMLN	DEG_APCC_DBOX_1	0.1389
p.R150H	TCGA-EO-A22R	UCEC	TCGA	MRKKLKMLN	DEG_APCC_DBOX_1	0.1389
p.I151V	TCGA-D1-A17F	UCEC	TCGA	MRKKLKMLN	DEG_APCC_DBOX_1	0.1111
p.A130S	DO228937	LICA	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	0.1944
p.A130S	DO229232	THCA	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	0.1944
p.D128Y	DO229009	LICA	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	0.1389
p.R141H	DO232224	PBCA	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	0.8244
p.R141H	DO41871	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	0.8244
p.R141H	DO42713	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	0.8244
p.A130T	DO229227	THCA	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	0.1944
p.K143N	DO219773	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	0.6918
p.I142V	DO43362	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	0.7076
p.T146M	DO52399	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	0.6944
p.A129T	SIDM00970	Bladder Carcinoma	GDSC	MRKKLKMLN	DEG_APCC_DBOX_1	0.1667
p.A129T	DSH1	urinary_tract	COSMIC	MRKKLKMLN	DEG_APCC_DBOX_1	0.1667
p.M135I	SIDM00150	Colorectal Carcinoma	GDSC	MRKKLKMLN	DEG_APCC_DBOX_1	0.6507
p.M135I	KM12	large_intestine	COSMIC	MRKKLKMLN	DEG_APCC_DBOX_1	0.6507
p.G127C	ACH-000966	Ovarian Cancer	CCLE	MRKKLKMLN	DEG_APCC_DBOX_1	0.1111
p.M126I	KM12	large_intestine	COSMIC	MRKKLKMLN	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY17	Patatin-like phospholipase domain-containing protein 6	DEG_APCC_DBOX_1	135:143	MRKKLKMLN	APC,CDC20,FZR1	0.6251	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons