DegronMD - Q8IY17(PNPLA6)

FUNCTION: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed:11927584). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed:11927584). {ECO:0000269|PubMed:11927584, ECO:0000269|PubMed:15044461}.

GO - Biological processes (BP): glycerophospholipid catabolic process [GO:0046475]; phosphatidylcholine metabolic process [GO:0046470]

GO - Molecular function (MF): lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]

GO - Cellular component (CC): cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; membrane [GO:0016020]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R141H	DO232224	PBCA	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.8244
p.R141H	DO41871	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.8244
p.R141H	DO42713	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.8244
p.P465H	SIDM00789	Colorectal Carcinoma	GDSC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.7694
p.P465H	HCT-15	large intestine	COSMIC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.7694
p.R463W	TCGA-AX-A2HC	UCEC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.7523
p.I142V	DO43362	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.7076
p.T146M	DO52399	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation blocking phosphorylation signal	0.6944
p.A465V	DO28014	OV	ICGC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6936
p.K461N	DO228952	LICA	ICGC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6918
p.K143N	DO219773	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.6918
p.M135I	SIDM00150	Colorectal Carcinoma	GDSC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.6507
p.M135I	KM12	large intestine	COSMIC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.6507
p.R463G	TCGA-CQ-7071	HNSC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6457
p.R463Q	TCGA-AJ-A3EK	UCEC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6218
p.R463Q	TCGA-EO-A22U	UCEC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6218
p.R463Q	TCGA-HU-8602	STAD	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6218
p.G455R	TCGA-BR-6802	STAD	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation blocking phosphorylation signal	0.6111
p.A462T	SIDM01560	Rhabdomyosarcoma	GDSC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6028
p.K140E	TCGA-AP-A1DK	UCEC	TCGA	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.591

Showing 1 to 20 of 44 entries

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Kaplan plot for PNPLA6 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

PNPLA6

UniProt ID: Q8IY17

Entrez ID: 10908

Protein name: Patatin-like phospholipase domain-containing protein 6 (EC 3.1.1.5) (Neuropathy target esterase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PNPLA6 in