DegronMD - Q8IY17(PNPLA6)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E471V	TCGA-33-A5GW	LUSC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.25
p.S454P	TCGA-3N-A9WC	SKCM	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.1389
p.R463Q	TCGA-AJ-A3EK	UCEC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6218
p.R463Q	TCGA-EO-A22U	UCEC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6218
p.R463Q	TCGA-HU-8602	STAD	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6218
p.K140E	TCGA-AP-A1DK	UCEC	TCGA	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.591
p.R463W	TCGA-AX-A2HC	UCEC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.7523
p.R150H	TCGA-B5-A3FC	UCEC	TCGA	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1389
p.R150H	TCGA-EO-A22R	UCEC	TCGA	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1389
p.G455R	TCGA-BR-6802	STAD	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation blocking phosphorylation signal	0.6111
p.R463G	TCGA-CQ-7071	HNSC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6457
p.I151V	TCGA-D1-A17F	UCEC	TCGA	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1111
p.E451D	TCGA-EO-A3AS	UCEC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.0556
p.A460S	DO219589	BRCA	ICGC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.3056
p.A453T	DO233869	GACA	ICGC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.1111
p.A130S	DO228937	LICA	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1944
p.A130S	DO229232	THCA	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1944
p.K461N	DO228952	LICA	ICGC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6918
p.R451L	DO228985	LICA	ICGC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.0556
p.R451L	DO229022	LICA	ICGC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.0556
p.D128Y	DO229009	LICA	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1389
p.A465V	DO28014	OV	ICGC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6936
p.R141H	DO232224	PBCA	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.8244
p.R141H	DO41871	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.8244
p.R141H	DO42713	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.8244
p.A130T	DO229227	THCA	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1944
p.K143N	DO219773	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.6918
p.I142V	DO43362	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.7076
p.T146M	DO52399	UCEC	ICGC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation blocking phosphorylation signal	0.6944
p.R451H	DO41871	UCEC	ICGC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.0556
p.P465H	SIDM00789	Colorectal Carcinoma	GDSC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.7694
p.P465H	HCT-15	large intestine	COSMIC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.7694
p.A129T	SIDM00970	Bladder Carcinoma	GDSC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1667
p.A129T	DSH1	urinary tract	COSMIC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1667
p.M135I	SIDM00150	Colorectal Carcinoma	GDSC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.6507
p.M135I	KM12	large intestine	COSMIC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.6507
p.A462T	SIDM01560	Rhabdomyosarcoma	GDSC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation altering degron motif	0.6028
p.R469W	ACH-000546	Head and Neck Cancer	CCLE	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.3056
p.R469W	ACH-000980	Lung Cancer	CCLE	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.3056
p.R469W	NCI-H1155	lung	COSMIC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.3056
p.R469W	HSC-4	upper aerodigestive tract	COSMIC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.3056
p.G127C	ACH-000966	Ovarian Cancer	CCLE	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1111
p.M126I	KM12	large intestine	COSMIC	MRKKLKMLN	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.0833
p.P456H	HCT-15	large intestine	COSMIC	PARTPTQE	DEG_SCF_FBW7_2	461:468	Mutation rewiring degron network	0.1944

Kaplan plot for PNPLA6 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PNPLA6

UniProt ID: Q8IY17

Entrez ID: 10908

Protein name: Patatin-like phospholipase domain-containing protein 6 (EC 3.1.1.5) (Neuropathy target esterase)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PNPLA6 in