DegronMD

Uniprot ID: Q8IY17

Source protein: Patatin-like phospholipase domain-containing protein 6

Source gene: PNPLA6

Class: DEG_SCF_FBW7_2

Location: 461:468

E3 ligase: FBXW7

DEGRON score: 0.9438

ASA_SCORE: 90.15

COIL: 0.8923

CONS_SCORE: 0.3532

DSS_SCORE: 0.7008

HELIX: 0.0389

FCONS_SCORE: 1.2693

RIG_SCORE: 0.6435

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E471V	TCGA-33-A5GW	LUSC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	0.25
p.S454P	TCGA-3N-A9WC	SKCM	TCGA	PARTPTQE	DEG_SCF_FBW7_2	0.1389
p.R463Q	TCGA-AJ-A3EK	UCEC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	0.6218
p.R463Q	TCGA-EO-A22U	UCEC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	0.6218
p.R463Q	TCGA-HU-8602	STAD	TCGA	PARTPTQE	DEG_SCF_FBW7_2	0.6218
p.R463W	TCGA-AX-A2HC	UCEC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	0.7523
p.G455R	TCGA-BR-6802	STAD	TCGA	PARTPTQE	DEG_SCF_FBW7_2	0.6111
p.R463G	TCGA-CQ-7071	HNSC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	0.6457
p.E451D	TCGA-EO-A3AS	UCEC	TCGA	PARTPTQE	DEG_SCF_FBW7_2	0.0556
p.A460S	DO219589	BRCA	ICGC	PARTPTQE	DEG_SCF_FBW7_2	0.3056
p.A453T	DO233869	GACA	ICGC	PARTPTQE	DEG_SCF_FBW7_2	0.1111
p.K461N	DO228952	LICA	ICGC	PARTPTQE	DEG_SCF_FBW7_2	0.6918
p.R451L	DO228985	LICA	ICGC	PARTPTQE	DEG_SCF_FBW7_2	0.0556
p.R451L	DO229022	LICA	ICGC	PARTPTQE	DEG_SCF_FBW7_2	0.0556
p.A465V	DO28014	OV	ICGC	PARTPTQE	DEG_SCF_FBW7_2	0.6936
p.R451H	DO41871	UCEC	ICGC	PARTPTQE	DEG_SCF_FBW7_2	0.0556
p.P465H	SIDM00789	Colorectal Carcinoma	GDSC	PARTPTQE	DEG_SCF_FBW7_2	0.7694
p.P465H	HCT-15	large_intestine	COSMIC	PARTPTQE	DEG_SCF_FBW7_2	0.7694
p.A462T	SIDM01560	Rhabdomyosarcoma	GDSC	PARTPTQE	DEG_SCF_FBW7_2	0.6028
p.R469W	ACH-000546	Head and Neck Cancer	CCLE	PARTPTQE	DEG_SCF_FBW7_2	0.3056
p.R469W	ACH-000980	Lung Cancer	CCLE	PARTPTQE	DEG_SCF_FBW7_2	0.3056
p.R469W	NCI-H1155	lung	COSMIC	PARTPTQE	DEG_SCF_FBW7_2	0.3056
p.R469W	HSC-4	upper_aerodigestive_tract	COSMIC	PARTPTQE	DEG_SCF_FBW7_2	0.3056
p.P456H	HCT-15	large_intestine	COSMIC	PARTPTQE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY17	Patatin-like phospholipase domain-containing protein 6	DEG_SCF_FBW7_2	461:468	PARTPTQE	FBXW7	0.9438	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons