DegronMD

Uniprot ID: Q9NTG1

Source protein: Polycystic kidney disease and receptor for egg jelly-related protein

Source gene: PKDREJ

Class: LIG_APCC_ABBA_1

Location: 1663:1668

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5958

ASA_SCORE: 93.25

COIL: 0.6152

CONS_SCORE: 0.3654

DSS_SCORE: 0.3678

HELIX: 0.294

FCONS_SCORE: 1.2512

RIG_SCORE: 0.7459

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1678L	TCGA-12-0778	GBM	TCGA	MRMHPE	LIG_APCC_ABBA_1	0.0556
p.V1678L	DO11411	GBM	ICGC	MRMHPE	LIG_APCC_ABBA_1	0.0556
p.R1664C	TCGA-69-8253	LUAD	TCGA	MRMHPE	LIG_APCC_ABBA_1	0.719
p.R1664C	DO23637	LUAD	ICGC	MRMHPE	LIG_APCC_ABBA_1	0.719
p.R1664C	SIDM01729	Endometrial Carcinoma	GDSC	MRMHPE	LIG_APCC_ABBA_1	0.719
p.R1664C	ACH-000909	Endometrial/Uterine Cancer	CCLE	MRMHPE	LIG_APCC_ABBA_1	0.719
p.I1658S	TCGA-AP-A059	UCEC	TCGA	MRMHPE	LIG_APCC_ABBA_1	0.1944
p.I1658S	DO41361	UCEC	ICGC	MRMHPE	LIG_APCC_ABBA_1	0.1944
p.E1657K	TCGA-CV-7089	HNSC	TCGA	MRMHPE	LIG_APCC_ABBA_1	0.1667
p.E1657K	DO15158	HNSC	ICGC	MRMHPE	LIG_APCC_ABBA_1	0.1667
p.D1661N	TCGA-D6-6516	HNSC	TCGA	MRMHPE	LIG_APCC_ABBA_1	0.2778
p.D1661N	DO15623	HNSC	ICGC	MRMHPE	LIG_APCC_ABBA_1	0.2778
p.M1663K	TCGA-DZ-6135	KIRP	TCGA	MRMHPE	LIG_APCC_ABBA_1	0.8062
p.M1663K	DO20926	KIRP	ICGC	MRMHPE	LIG_APCC_ABBA_1	0.8062
p.R1672K	TCGA-QB-A6FS	SKCM	TCGA	MRMHPE	LIG_APCC_ABBA_1	0.2222
p.R1672K	DO48654	SKCM	ICGC	MRMHPE	LIG_APCC_ABBA_1	0.2222
p.R1659G	DO233210	GACA	ICGC	MRMHPE	LIG_APCC_ABBA_1	0.2222
p.V1678I	DO233737	GACA	ICGC	MRMHPE	LIG_APCC_ABBA_1	0.0556
p.V1678I	ACH-001850	Gallbladder Cancer	CCLE	MRMHPE	LIG_APCC_ABBA_1	0.0556
p.E1657D	DO50806	LIRI	ICGC	MRMHPE	LIG_APCC_ABBA_1	0.1667
p.L1660F	DO222572	MELA	ICGC	MRMHPE	LIG_APCC_ABBA_1	0.25
p.R1664H	SIDM00656	Burkitt's Lymphoma	GDSC	MRMHPE	LIG_APCC_ABBA_1	0.7133
p.R1664H	ACH-000944	Lymphoma	CCLE	MRMHPE	LIG_APCC_ABBA_1	0.7133
p.R1664H	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	MRMHPE	LIG_APCC_ABBA_1	0.7133
p.H1666Y	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	MRMHPE	LIG_APCC_ABBA_1	0.6118
p.H1666Y	ACH-000843	Lung Cancer	CCLE	MRMHPE	LIG_APCC_ABBA_1	0.6118
p.H1666Y	HARA	lung	COSMIC	MRMHPE	LIG_APCC_ABBA_1	0.6118

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NTG1	Polycystic kidney disease and receptor for egg jelly-related protein	LIG_APCC_ABBA_1	1663:1668	MRMHPE	APC,CDC20,FZR1	0.5958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MRMHPE

Degron related mutations and impact score

Drug responses associated with PKDREJ mutations

All proteins holding degron of MRMHPE