DegronMD - Q9NTG1(PKDREJ)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1678L	TCGA-12-0778	GBM	TCGA	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.0556
p.V1678L	DO11411	GBM	ICGC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.0556
p.R1664C	TCGA-69-8253	LUAD	TCGA	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.719
p.R1664C	DO23637	LUAD	ICGC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.719
p.R1664C	SIDM01729	Endometrial Carcinoma	GDSC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.719
p.R1664C	ACH-000909	Endometrial/Uterine Cancer	CCLE	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.719
p.I1658S	TCGA-AP-A059	UCEC	TCGA	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.1944
p.I1658S	DO41361	UCEC	ICGC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.1944
p.E1657K	TCGA-CV-7089	HNSC	TCGA	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.1667
p.E1657K	DO15158	HNSC	ICGC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.1667
p.D1661N	TCGA-D6-6516	HNSC	TCGA	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.2778
p.D1661N	DO15623	HNSC	ICGC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.2778
p.M1663K	TCGA-DZ-6135	KIRP	TCGA	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.8062
p.M1663K	DO20926	KIRP	ICGC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.8062
p.R172Q	TCGA-FI-A2D0	UCEC	TCGA	SPAARVSPR	DEG_SIAH_1	157:165	Mutation rewiring degron network	0.1389
p.R172Q	DO43891	UCEC	ICGC	SPAARVSPR	DEG_SIAH_1	157:165	Mutation rewiring degron network	0.1389
p.P171R	TCGA-MI-A75E	LIHC	TCGA	SPAARVSPR	DEG_SIAH_1	157:165	Mutation rewiring degron network	0.1667
p.P171R	DO49707	LIHC	ICGC	SPAARVSPR	DEG_SIAH_1	157:165	Mutation rewiring degron network	0.1667
p.R1672K	TCGA-QB-A6FS	SKCM	TCGA	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.2222
p.R1672K	DO48654	SKCM	ICGC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.2222
p.S163T	DO225193	BRCA	ICGC	SPAARVSPR	DEG_SIAH_1	157:165	Mutation altering degron motif	0.6005
p.R1659G	DO233210	GACA	ICGC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.2222
p.V1678I	DO233737	GACA	ICGC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.0556
p.V1678I	ACH-001850	Gallbladder Cancer	CCLE	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.0556
p.A160V	DO50970	LICA	ICGC	SPAARVSPR	DEG_SIAH_1	157:165	Mutation altering degron motif	0.6936
p.E1657D	DO50806	LIRI	ICGC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.1667
p.L1660F	DO222572	MELA	ICGC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation rewiring degron network	0.25
p.R154H	DO228668	PRAD	ICGC	SPAARVSPR	DEG_SIAH_1	157:165	Mutation rewiring degron network	0.25
p.S157P	DO219881	SKCA	ICGC	SPAARVSPR	DEG_SIAH_1	157:165	Mutation altering degron motif	0.5641
p.Q175R	DO229272	THCA	ICGC	SPAARVSPR	DEG_SIAH_1	157:165	Mutation rewiring degron network	0.0556
p.R1664H	SIDM00656	Burkitt's Lymphoma	GDSC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.7133
p.R1664H	ACH-000944	Lymphoma	CCLE	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.7133
p.R1664H	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.7133
p.H1666Y	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.6118
p.H1666Y	ACH-000843	Lung Cancer	CCLE	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.6118
p.H1666Y	HARA	lung	COSMIC	MRMHPE	LIG_APCC_ABBA_1	1663:1668	Mutation altering degron motif	0.6118

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKDREJ

UniProt ID: Q9NTG1

Entrez ID: 10343

Protein name: Polycystic kidney disease and receptor for egg jelly-related protein (PKD and REJ homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKDREJ in