DegronMD

Uniprot ID: Q9NTG1

Source protein: Polycystic kidney disease and receptor for egg jelly-related protein

Source gene: PKDREJ

Class: DEG_SIAH_1

Location: 157:165

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.5027

ASA_SCORE: 53.7

COIL: 0.6444

CONS_SCORE: 0.374

DSS_SCORE: 0.6394

HELIX: 0.2073

FCONS_SCORE: 1.0601

RIG_SCORE: 0.6244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R172Q	TCGA-FI-A2D0	UCEC	TCGA	SPAARVSPR	DEG_SIAH_1	0.1389
p.R172Q	DO43891	UCEC	ICGC	SPAARVSPR	DEG_SIAH_1	0.1389
p.P171R	TCGA-MI-A75E	LIHC	TCGA	SPAARVSPR	DEG_SIAH_1	0.1667
p.P171R	DO49707	LIHC	ICGC	SPAARVSPR	DEG_SIAH_1	0.1667
p.S163T	DO225193	BRCA	ICGC	SPAARVSPR	DEG_SIAH_1	0.6005
p.A160V	DO50970	LICA	ICGC	SPAARVSPR	DEG_SIAH_1	0.6936
p.R154H	DO228668	PRAD	ICGC	SPAARVSPR	DEG_SIAH_1	0.25
p.S157P	DO219881	SKCA	ICGC	SPAARVSPR	DEG_SIAH_1	0.5641
p.Q175R	DO229272	THCA	ICGC	SPAARVSPR	DEG_SIAH_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NTG1	Polycystic kidney disease and receptor for egg jelly-related protein	DEG_SIAH_1	157:165	SPAARVSPR	SIAH1,SIAH2,SIAH3	0.5027	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons