DegronMD

Uniprot ID: P81877

Source protein: Single-stranded DNA-binding protein 2

Source gene: SSBP2

Class: DEG_APCC_DBOX_1

Location: 196:204

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9409

ASA_SCORE: 63.7444

COIL: 0.9064

CONS_SCORE: 0.418

DSS_SCORE: 0.5457

HELIX: 0.0406

FCONS_SCORE: 0.8591

RIG_SCORE: 0.6506

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M213I	TCGA-D3-A3ML	SKCM	TCGA	MRPPLNALG	DEG_APCC_DBOX_1	0.0833
p.M213I	DO47413	SKCM	ICGC	MRPPLNALG	DEG_APCC_DBOX_1	0.0833
p.G210V	TCGA-EE-A2MS	SKCM	TCGA	MRPPLNALG	DEG_APCC_DBOX_1	0.1667
p.G210V	DO37567	SKCM	ICGC	MRPPLNALG	DEG_APCC_DBOX_1	0.1667
p.P198H	TCGA-FS-A1ZU	SKCM	TCGA	MRPPLNALG	DEG_APCC_DBOX_1	0.6583
p.P206H	TCGA-IB-7651	PAAD	TCGA	MRPPLNALG	DEG_APCC_DBOX_1	0.2778
p.P206H	DO46657	PAAD	ICGC	MRPPLNALG	DEG_APCC_DBOX_1	0.2778
p.M186I	DO8264	COAD	ICGC	MRPPLNALG	DEG_APCC_DBOX_1	0.0556
p.M186I	ONS-76	central_nervous_system	COSMIC	MRPPLNALG	DEG_APCC_DBOX_1	0.0556
p.G205D	DO233869	GACA	ICGC	MRPPLNALG	DEG_APCC_DBOX_1	0.3056
p.P206T	DO222562	MELA	ICGC	MRPPLNALG	DEG_APCC_DBOX_1	0.2778
p.G210E	DO232761	PBCA	ICGC	MRPPLNALG	DEG_APCC_DBOX_1	0.1667
p.Q190H	SIDM00282	Colorectal Carcinoma	GDSC	MRPPLNALG	DEG_APCC_DBOX_1	0.1667
p.Q190H	CW-2	large_intestine	COSMIC	MRPPLNALG	DEG_APCC_DBOX_1	0.1667
p.M208I	ACH-000776	Brain Cancer	CCLE	MRPPLNALG	DEG_APCC_DBOX_1	0.2222
p.M208I	ONS-76	central_nervous_system	COSMIC	MRPPLNALG	DEG_APCC_DBOX_1	0.2222
p.A205P	NCI-H1755	lung	COSMIC	MRPPLNALG	DEG_APCC_DBOX_1	0.3056
p.A197P	NCI-H1755	lung	COSMIC	MRPPLNALG	DEG_APCC_DBOX_1	0.7503
p.A207P	NCI-H1755	lung	COSMIC	MRPPLNALG	DEG_APCC_DBOX_1	0.25
p.P214T	RF-48	stomach	COSMIC	MRPPLNALG	DEG_APCC_DBOX_1	0.0556
p.M188I	ONS-76	central_nervous_system	COSMIC	MRPPLNALG	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P81877	Single-stranded DNA-binding protein 2	DEG_APCC_DBOX_1	196:204	MRPPLNALG	APC,CDC20,FZR1	0.9409	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons