DegronMD

Uniprot ID: Q8TEQ0

Source protein: Sorting nexin-29

Source gene: SNX29

Class: DEG_APCC_DBOX_1

Location: 623:631

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8334

ASA_SCORE: 88.9333

COIL: 0.3182

CONS_SCORE: 0.5271

DSS_SCORE: 0.3511

HELIX: 0.6651

FCONS_SCORE: 1.1376

RIG_SCORE: 0.7929

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R631Q	TCGA-AD-6889	COAD	TCGA	MRQELIDLR	DEG_APCC_DBOX_1	0.6218
p.R631Q	SIDM01233	Colorectal Carcinoma	GDSC	MRQELIDLR	DEG_APCC_DBOX_1	0.6218
p.R631Q	ACH-000009	Colon/Colorectal Cancer	CCLE	MRQELIDLR	DEG_APCC_DBOX_1	0.6218
p.R631Q	C2BBe1	large_intestine	COSMIC	MRQELIDLR	DEG_APCC_DBOX_1	0.6218
p.D637Y	TCGA-AG-A002	READ	TCGA	MRQELIDLR	DEG_APCC_DBOX_1	0.1667
p.D629N	TCGA-BR-6452	STAD	TCGA	MRQELIDLR	DEG_APCC_DBOX_1	0.5821
p.M623V	TCGA-EO-A3AY	UCEC	TCGA	MRQELIDLR	DEG_APCC_DBOX_1	0.6097
p.E617V	TCGA-F5-6864	READ	TCGA	MRQELIDLR	DEG_APCC_DBOX_1	0.1667
p.P633S	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	MRQELIDLR	DEG_APCC_DBOX_1	0.2778
p.P633S	SIDM00640	Mesothelioma	GDSC	MRQELIDLR	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEQ0	Sorting nexin-29	DEG_APCC_DBOX_1	623:631	MRQELIDLR	APC,CDC20,FZR1	0.8334	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons