DegronMD - Q8TEQ0(SNX29)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R631Q	TCGA-AD-6889	COAD	TCGA	MRQELIDLR	DEG_APCC_DBOX_1	623:631	Mutation altering degron motif	0.6218
p.R631Q	SIDM01233	Colorectal Carcinoma	GDSC	MRQELIDLR	DEG_APCC_DBOX_1	623:631	Mutation altering degron motif	0.6218
p.R631Q	ACH-000009	Colon/Colorectal Cancer	CCLE	MRQELIDLR	DEG_APCC_DBOX_1	623:631	Mutation altering degron motif	0.6218
p.R631Q	C2BBe1	large intestine	COSMIC	MRQELIDLR	DEG_APCC_DBOX_1	623:631	Mutation altering degron motif	0.6218
p.D637Y	TCGA-AG-A002	READ	TCGA	MRQELIDLR	DEG_APCC_DBOX_1	623:631	Mutation rewiring degron network	0.1667
p.G779R	TCGA-B5-A1MX	UCEC	TCGA	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.6457
p.D629N	TCGA-BR-6452	STAD	TCGA	MRQELIDLR	DEG_APCC_DBOX_1	623:631	Mutation altering degron motif	0.5821
p.T776I	TCGA-D3-A3C3	SKCM	TCGA	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.7078
p.V773I	TCGA-DM-A288	COAD	TCGA	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.5965
p.V773I	SIDM01619	Endometrial Carcinoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.5965
p.P777S	TCGA-DX-AB2E	SARC	TCGA	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.6752
p.P777S	SIDM00203	Ewing's Sarcoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.6752
p.P777S	ACH-002111	Bone Cancer	CCLE	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.6752
p.P770S	TCGA-EB-A44O	SKCM	TCGA	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation rewiring degron network	0.25
p.P777Q	TCGA-EE-A29S	SKCM	TCGA	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.7035
p.G779E	TCGA-EE-A2GJ	SKCM	TCGA	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.6087
p.M623V	TCGA-EO-A3AY	UCEC	TCGA	MRQELIDLR	DEG_APCC_DBOX_1	623:631	Mutation altering degron motif	0.6097
p.E617V	TCGA-F5-6864	READ	TCGA	MRQELIDLR	DEG_APCC_DBOX_1	623:631	Mutation rewiring degron network	0.1667
p.R785Q	SIDM00454	Rhabdomyosarcoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation rewiring degron network	0.1944
p.P633S	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	MRQELIDLR	DEG_APCC_DBOX_1	623:631	Mutation rewiring degron network	0.2778
p.P633S	SIDM00640	Mesothelioma	GDSC	MRQELIDLR	DEG_APCC_DBOX_1	623:631	Mutation rewiring degron network	0.2778
p.P777L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.7582
p.P777L	ACH-000960	Leukemia	CCLE	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.7582
p.P777L	REH	haematopoietic and lymphoid tissue	COSMIC	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation altering degron motif	0.7582
p.R785W	SIDM00210	Ovarian Carcinoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation rewiring degron network	0.1944
p.Q767K	SIDM00901	Endometrial Carcinoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation rewiring degron network	0.1667
p.Q767K	ACH-000940	Endometrial/Uterine Cancer	CCLE	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation rewiring degron network	0.1667
p.Q767K	AN3-CA	endometrium	COSMIC	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation rewiring degron network	0.1667
p.P786T	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	773:780	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNX29

UniProt ID: Q8TEQ0

Entrez ID: 92017

Protein name: Sorting nexin-29 (RUN domain-containing protein 2A)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SNX29 in