DegronMD

Uniprot ID: Q8TEQ0

Source protein: Sorting nexin-29

Source gene: SNX29

Class: DEG_SCF_FBW7_2

Location: 773:780

E3 ligase: FBXW7

DEGRON score: 0.995

ASA_SCORE: 80.3625

COIL: 0.8884

CONS_SCORE: 0.3207

DSS_SCORE: 0.4052

HELIX: 0.0396

FCONS_SCORE: 0.7542

RIG_SCORE: 0.7177

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G779R	TCGA-B5-A1MX	UCEC	TCGA	VDITPPGE	DEG_SCF_FBW7_2	0.6457
p.T776I	TCGA-D3-A3C3	SKCM	TCGA	VDITPPGE	DEG_SCF_FBW7_2	0.7078
p.V773I	TCGA-DM-A288	COAD	TCGA	VDITPPGE	DEG_SCF_FBW7_2	0.5965
p.V773I	SIDM01619	Endometrial Carcinoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	0.5965
p.P777S	TCGA-DX-AB2E	SARC	TCGA	VDITPPGE	DEG_SCF_FBW7_2	0.6752
p.P777S	SIDM00203	Ewing's Sarcoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	0.6752
p.P777S	ACH-002111	Bone Cancer	CCLE	VDITPPGE	DEG_SCF_FBW7_2	0.6752
p.P770S	TCGA-EB-A44O	SKCM	TCGA	VDITPPGE	DEG_SCF_FBW7_2	0.25
p.P777Q	TCGA-EE-A29S	SKCM	TCGA	VDITPPGE	DEG_SCF_FBW7_2	0.7035
p.G779E	TCGA-EE-A2GJ	SKCM	TCGA	VDITPPGE	DEG_SCF_FBW7_2	0.6087
p.R785Q	SIDM00454	Rhabdomyosarcoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	0.1944
p.P777L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VDITPPGE	DEG_SCF_FBW7_2	0.7582
p.P777L	ACH-000960	Leukemia	CCLE	VDITPPGE	DEG_SCF_FBW7_2	0.7582
p.P777L	REH	haematopoietic_and_lymphoid_tissue	COSMIC	VDITPPGE	DEG_SCF_FBW7_2	0.7582
p.R785W	SIDM00210	Ovarian Carcinoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	0.1944
p.Q767K	SIDM00901	Endometrial Carcinoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	0.1667
p.Q767K	ACH-000940	Endometrial/Uterine Cancer	CCLE	VDITPPGE	DEG_SCF_FBW7_2	0.1667
p.Q767K	AN3-CA	endometrium	COSMIC	VDITPPGE	DEG_SCF_FBW7_2	0.1667
p.P786T	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	VDITPPGE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEQ0	Sorting nexin-29	DEG_SCF_FBW7_2	773:780	VDITPPGE	FBXW7	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons