DegronMD

Uniprot ID: Q99969

Source protein: Retinoic acid receptor responder protein 2

Source gene: RARRES2

Class: DEG_APCC_DBOX_1

Location: 1:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.883

ASA_SCORE: 89.9222

COIL: 0.3177

CONS_SCORE: 0.7914

DSS_SCORE: 0.164

HELIX: 0.6628

FCONS_SCORE: 1.2911

RIG_SCORE: 0.918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A9T	TCGA-EO-A22U	UCEC	TCGA	MRRLLIPLA	DEG_APCC_DBOX_1	0.6028
p.A9T	DO43755	UCEC	ICGC	MRRLLIPLA	DEG_APCC_DBOX_1	0.6028
p.R2G	DO224541	LUSC	ICGC	MRRLLIPLA	DEG_APCC_DBOX_1	0.7568
p.R2G	DO231003	LUSC	ICGC	MRRLLIPLA	DEG_APCC_DBOX_1	0.7568
p.A14T	SIDM01608	Endometrial Carcinoma	GDSC	MRRLLIPLA	DEG_APCC_DBOX_1	0.1944
p.A14T	ACH-000990	Endometrial/Uterine Cancer	CCLE	MRRLLIPLA	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99969	Retinoic acid receptor responder protein 2	DEG_APCC_DBOX_1	1:9	MRRLLIPLA	APC,CDC20,FZR1	0.883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons