DegronMD

Uniprot ID: P57740

Source protein: Nuclear pore complex protein Nup107

Source gene: NUP107

Class: LIG_APCC_ABBA_1

Location: 152:157

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9873

ASA_SCORE: 51.3667

COIL: 0.084

CONS_SCORE: 0.3521

DSS_SCORE: 0.244

HELIX: 0.9102

FCONS_SCORE: 1.3999

RIG_SCORE: 0.7913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E143D	TCGA-CG-4305	STAD	TCGA	MSMFSD	LIG_APCC_ABBA_1	0.0833
p.M152I	TCGA-FD-A6TG	BLCA	TCGA	MSMFSD	LIG_APCC_ABBA_1	0.6507
p.R166H	DO51883	BLCA	ICGC	MSMFSD	LIG_APCC_ABBA_1	0.0833
p.R166H	SNU-398	liver	COSMIC	MSMFSD	LIG_APCC_ABBA_1	0.0833
p.V162I	DO44178	BRCA	ICGC	MSMFSD	LIG_APCC_ABBA_1	0.1944
p.H151Y	DO234230	ESAD	ICGC	MSMFSD	LIG_APCC_ABBA_1	0.3056
p.V165F	DO229045	LICA	ICGC	MSMFSD	LIG_APCC_ABBA_1	0.1111
p.E147D	DO45035	LINC	ICGC	MSMFSD	LIG_APCC_ABBA_1	0.1944
p.T149A	DO24218	LUAD	ICGC	MSMFSD	LIG_APCC_ABBA_1	0.25
p.R166C	DO222415	MELA	ICGC	MSMFSD	LIG_APCC_ABBA_1	0.0833
p.R156L	DO28923	OV	ICGC	MSMFSD	LIG_APCC_ABBA_1	0.8428
p.R156L	HCC1428	breast	COSMIC	MSMFSD	LIG_APCC_ABBA_1	0.8428
p.T149N	DO51407	PRAD	ICGC	MSMFSD	LIG_APCC_ABBA_1	0.25
p.M152V	SIDM00217	Colorectal Carcinoma	GDSC	MSMFSD	LIG_APCC_ABBA_1	0.6097
p.F155L	SIDM00217	Colorectal Carcinoma	GDSC	MSMFSD	LIG_APCC_ABBA_1	0.6981
p.Q155H	HCT-15	large_intestine	COSMIC	MSMFSD	LIG_APCC_ABBA_1	0.7582
p.P167L	TMK-1	stomach	COSMIC	MSMFSD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P57740	Nuclear pore complex protein Nup107	LIG_APCC_ABBA_1	152:157	MSMFSD	APC,CDC20,FZR1	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons