DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 184:190

E3 ligase: FBXW7

DEGRON score: 0.9433

ASA_SCORE: 91.7571

COIL: 0.8366

CONS_SCORE: 0.5236

DSS_SCORE: 0.445

HELIX: 0.0134

FCONS_SCORE: 0.9989

RIG_SCORE: 0.7205

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A174V	TCGA-49-4505	LUAD	TCGA	MSTPLTT	DEG_SCF_FBW7_1	0.0556
p.A174V	DO25498	LUAD	ICGC	MSTPLTT	DEG_SCF_FBW7_1	0.0556
p.T186A	TCGA-F7-A624	HNSC	TCGA	MSTPLTT	DEG_SCF_FBW7_1	0.7139
p.T186A	DO44440	HNSC	ICGC	MSTPLTT	DEG_SCF_FBW7_1	0.7139
p.P187S	TCGA-FW-A3R5	SKCM	TCGA	MSTPLTT	DEG_SCF_FBW7_1	0.6752
p.P187S	DO37406	SKCM	ICGC	MSTPLTT	DEG_SCF_FBW7_1	0.6752
p.S195R	TCGA-VQ-A94R	STAD	TCGA	MSTPLTT	DEG_SCF_FBW7_1	0.1944
p.S195R	DO222372	STAD	ICGC	MSTPLTT	DEG_SCF_FBW7_1	0.1944
p.L178F	TCGA-Z2-A8RT	SKCM	TCGA	MSTPLTT	DEG_SCF_FBW7_1	0.1667
p.L178F	DO51301	SKCM	ICGC	MSTPLTT	DEG_SCF_FBW7_1	0.1667
p.T199I	DO234321	ESAD	ICGC	MSTPLTT	DEG_SCF_FBW7_1	0.0833
p.S196L	DO220877	MELA	ICGC	MSTPLTT	DEG_SCF_FBW7_1	0.1667
p.P187L	DO47174	RECA	ICGC	MSTPLTT	DEG_SCF_FBW7_1	0.7582
p.A194E	SIDM00506	Small Cell Lung Carcinoma	GDSC	MSTPLTT	DEG_SCF_FBW7_1	0.2222
p.A194E	COR-L88	lung	COSMIC	MSTPLTT	DEG_SCF_FBW7_1	0.2222
p.A194T	SIDM00118	Colorectal Carcinoma	GDSC	MSTPLTT	DEG_SCF_FBW7_1	0.2222
p.A194T	ACH-001081	Colon/Colorectal Cancer	CCLE	MSTPLTT	DEG_SCF_FBW7_1	0.2222
p.A194T	HCC2998	large_intestine	COSMIC	MSTPLTT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	184:190	MSTPLTT	FBXW7	0.9433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons