DegronMD

Uniprot ID: Q8IYY4

Source protein: Cilium assembly protein DZIP1L

Source gene: DZIP1L

Class: DEG_SCF_FBW7_1

Location: 610:616

E3 ligase: FBXW7

DEGRON score: 0.9524

ASA_SCORE: 89.8143

COIL: 0.9609

CONS_SCORE: 0.3863

DSS_SCORE: 0.8398

HELIX: 0.0086

FCONS_SCORE: 1.1345

RIG_SCORE: 0.4985

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P614Q	TCGA-95-7039	LUAD	TCGA	MSTPPFS	DEG_SCF_FBW7_1	0.5924
p.P614Q	DO23907	LUAD	ICGC	MSTPPFS	DEG_SCF_FBW7_1	0.5924
p.R625H	DO233116	GACA	ICGC	MSTPPFS	DEG_SCF_FBW7_1	0.0833
p.R625H	SIDM01665	Colorectal Carcinoma	GDSC	MSTPPFS	DEG_SCF_FBW7_1	0.0833
p.G609E	DO50970	LICA	ICGC	MSTPPFS	DEG_SCF_FBW7_1	0.3056
p.R625P	DO229221	THCA	ICGC	MSTPPFS	DEG_SCF_FBW7_1	0.0833
p.P614L	SIDM02065	Colorectal Carcinoma	GDSC	MSTPPFS	DEG_SCF_FBW7_1	0.6471
p.E622G	SIDM01018	Hodgkin's Lymphoma	GDSC	MSTPPFS	DEG_SCF_FBW7_1	0.1667
p.E622G	ACH-000815	Lymphoma	CCLE	MSTPPFS	DEG_SCF_FBW7_1	0.1667
p.E622G	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	MSTPPFS	DEG_SCF_FBW7_1	0.1667
p.M610I	SIDM00720	Mesothelioma	GDSC	MSTPPFS	DEG_SCF_FBW7_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYY4	Cilium assembly protein DZIP1L	DEG_SCF_FBW7_1	610:616	MSTPPFS	FBXW7	0.9524	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons