DegronMD - Q8IYY4(DZIP1L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A589S	TCGA-17-Z036	LUAD	TCGA	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.0556
p.P614Q	TCGA-95-7039	LUAD	TCGA	MSTPPFS	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.5924
p.P614Q	DO23907	LUAD	ICGC	MSTPPFS	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.5924
p.A589V	TCGA-AP-A059	UCEC	TCGA	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.0556
p.A589V	DO41361	UCEC	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.0556
p.P592A	TCGA-EK-A3GK	CESC	TCGA	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.1389
p.P592A	DO49964	CESC	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.1389
p.A591T	TCGA-IB-7651	PAAD	TCGA	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.1111
p.A591T	DO46657	PAAD	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.1111
p.R593H	DO48360	BLCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.1667
p.R593H	DO229010	COCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.1667
p.R593H	DO229013	COCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.1667
p.R593H	DO229016	COCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.1667
p.R593H	DO229003	COCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.1667
p.R593H	DO229005	COCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.1667
p.R593H	DO51028	LAML	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.1667
p.R625H	DO233116	GACA	ICGC	MSTPPFS	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.0833
p.R625H	SIDM01665	Colorectal Carcinoma	GDSC	MSTPPFS	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.0833
p.H597Y	DO233284	GACA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.2778
p.G609E	DO50970	LICA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.25
p.G609E	DO50970	LICA	ICGC	MSTPPFS	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.3056
p.G595E	DO230993	LUSC	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.2222
p.P590S	DO222696	MELA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.0833
p.R625P	DO229221	THCA	ICGC	MSTPPFS	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.0833
p.P614L	SIDM02065	Colorectal Carcinoma	GDSC	MSTPPFS	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.6471
p.S600A	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation altering degron motif	0.6477
p.S600A	ACH-000860	Lung Cancer	CCLE	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation altering degron motif	0.6477
p.S606L	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation altering degron motif	0.7667
p.S606L	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation altering degron motif	0.7667
p.E622G	SIDM01018	Hodgkin's Lymphoma	GDSC	MSTPPFS	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1667
p.E622G	ACH-000815	Lymphoma	CCLE	MSTPPFS	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1667
p.E622G	KM-H2	haematopoietic and lymphoid tissue	COSMIC	MSTPPFS	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1667
p.M610I	SIDM00720	Mesothelioma	GDSC	MSTPPFS	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.6507
p.A589T	SIDM01608	Endometrial Carcinoma	GDSC	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation rewiring degron network	0.0556
p.P599S	ACH-001306	Thyroid Cancer	CCLE	PSSTPPSS	DEG_SCF_FBW7_1	599:606	Mutation altering degron motif	0.6752

Kaplan plot for DZIP1L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DZIP1L

UniProt ID: Q8IYY4

Entrez ID: 199221

Protein name: Cilium assembly protein DZIP1L (DAZ-interacting zinc finger protein 1-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DZIP1L in