DegronMD

Uniprot ID: Q8IYY4

Source protein: Cilium assembly protein DZIP1L

Source gene: DZIP1L

Class: DEG_SCF_FBW7_1

Location: 599:606

E3 ligase: FBXW7

DEGRON score: 0.6534

ASA_SCORE: 94.7125

COIL: 0.9786

CONS_SCORE: 0.3429

DSS_SCORE: 0.8611

HELIX: 0.0089

FCONS_SCORE: 0.94

RIG_SCORE: 0.4364

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A589S	TCGA-17-Z036	LUAD	TCGA	PSSTPPSS	DEG_SCF_FBW7_1	0.0556
p.A589V	TCGA-AP-A059	UCEC	TCGA	PSSTPPSS	DEG_SCF_FBW7_1	0.0556
p.A589V	DO41361	UCEC	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.0556
p.P592A	TCGA-EK-A3GK	CESC	TCGA	PSSTPPSS	DEG_SCF_FBW7_1	0.1389
p.P592A	DO49964	CESC	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.1389
p.A591T	TCGA-IB-7651	PAAD	TCGA	PSSTPPSS	DEG_SCF_FBW7_1	0.1111
p.A591T	DO46657	PAAD	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.1111
p.R593H	DO48360	BLCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.1667
p.R593H	DO229010	COCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.1667
p.R593H	DO229013	COCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.1667
p.R593H	DO229016	COCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.1667
p.R593H	DO229003	COCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.1667
p.R593H	DO229005	COCA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.1667
p.R593H	DO51028	LAML	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.1667
p.H597Y	DO233284	GACA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.2778
p.G609E	DO50970	LICA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.25
p.G595E	DO230993	LUSC	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.2222
p.P590S	DO222696	MELA	ICGC	PSSTPPSS	DEG_SCF_FBW7_1	0.0833
p.S600A	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PSSTPPSS	DEG_SCF_FBW7_1	0.6477
p.S600A	ACH-000860	Lung Cancer	CCLE	PSSTPPSS	DEG_SCF_FBW7_1	0.6477
p.S606L	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PSSTPPSS	DEG_SCF_FBW7_1	0.7667
p.S606L	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPPSS	DEG_SCF_FBW7_1	0.7667
p.A589T	SIDM01608	Endometrial Carcinoma	GDSC	PSSTPPSS	DEG_SCF_FBW7_1	0.0556
p.P599S	ACH-001306	Thyroid Cancer	CCLE	PSSTPPSS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYY4	Cilium assembly protein DZIP1L	DEG_SCF_FBW7_1	599:606	PSSTPPSS	FBXW7	0.6534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons