DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 3122:3128

E3 ligase: FBXW7

DEGRON score: 0.9626

ASA_SCORE: 86.7286

COIL: 0.935

CONS_SCORE: 0.2025

DSS_SCORE: 0.6176

HELIX: 0.015

FCONS_SCORE: -0.0006

RIG_SCORE: 0.637

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3117K	TCGA-44-7662	LUAD	TCGA	MSTPSST	DEG_SCF_FBW7_1	0.1944
p.R3117W	TCGA-49-6743	LUAD	TCGA	MSTPSST	DEG_SCF_FBW7_1	0.1944
p.R3117M	TCGA-49-6743	LUAD	TCGA	MSTPSST	DEG_SCF_FBW7_1	0.1944
p.S3127T	TCGA-56-7823	LUSC	TCGA	MSTPSST	DEG_SCF_FBW7_1	0.6005
p.G3130R	TCGA-DX-AB2E	SARC	TCGA	MSTPSST	DEG_SCF_FBW7_1	0.2778
p.P3129L	TCGA-FR-A3YN	SKCM	TCGA	MSTPSST	DEG_SCF_FBW7_1	0.3056
p.P3129L	TCGA-VQ-A91D	STAD	TCGA	MSTPSST	DEG_SCF_FBW7_1	0.3056
p.P3129L	SIDM00003	Melanoma	GDSC	MSTPSST	DEG_SCF_FBW7_1	0.3056
p.P3129L	M14	skin	COSMIC	MSTPSST	DEG_SCF_FBW7_1	0.3056
p.I3134F	TCGA-FS-A1YW	SKCM	TCGA	MSTPSST	DEG_SCF_FBW7_1	0.1667
p.T3115M	TCGA-G4-6320	COAD	TCGA	MSTPSST	DEG_SCF_FBW7_1	0.1389
p.T3118M	DO49265	ALL	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.2222
p.T3118M	DO8159	COAD	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.2222
p.M3125T	DO224721	COCA	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.7423
p.M3125T	DO222752	COCA	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.7423
p.M3125T	DO229010	COCA	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.7423
p.M3125T	DO229013	COCA	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.7423
p.M3125T	DO52370	LUSC	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.7423
p.T3135I	DO229052	LICA	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.1389
p.R3120K	DO23597	LUAD	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.2778
p.R3120M	DO26092	LUAD	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.2778
p.R3120W	DO26092	LUAD	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.2778
p.S3130T	DO223721	LUSC	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.2778
p.A3121V	DO222635	MELA	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.3056
p.G3133R	DO220073	SARC	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.1944
p.I3137F	DO37734	SKCM	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.0833
p.P3132L	DO38111	SKCM	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.2222
p.P3132L	DO51783	STAD	ICGC	MSTPSST	DEG_SCF_FBW7_1	0.2222
p.S3123F	SIDM00135	Breast Carcinoma	GDSC	MSTPSST	DEG_SCF_FBW7_1	0.6871
p.S3126A	SIDM01045	Endometrial Carcinoma	GDSC	MSTPSST	DEG_SCF_FBW7_1	0.6477
p.S3126A	ACH-000978	Endometrial/Uterine Cancer	CCLE	MSTPSST	DEG_SCF_FBW7_1	0.6477
p.S3126A	EN	endometrium	COSMIC	MSTPSST	DEG_SCF_FBW7_1	0.6477

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MSTPSST

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of MSTPSST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3122:3128	MSTPSST	FBXW7	0.9626	More...