DegronMD

Uniprot ID: Q8TDW5

Source protein: Synaptotagmin-like protein 5

Source gene: SYTL5

Class: LIG_APCC_ABBA_1

Location: 392:397

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5661

ASA_SCORE: 74.6167

COIL: 0.5125

CONS_SCORE: 0.7088

DSS_SCORE: 0.231

HELIX: 0.1712

FCONS_SCORE: 1.1819

RIG_SCORE: 0.7772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L383I	TCGA-06-5416	GBM	TCGA	MSVYSE	LIG_APCC_ABBA_1	0.0833
p.L383I	TCGA-69-7980	LUAD	TCGA	MSVYSE	LIG_APCC_ABBA_1	0.0833
p.L383I	DO10880	GBM	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.0833
p.L383I	DO23678	LUAD	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.0833
p.L383Q	TCGA-69-7980	LUAD	TCGA	MSVYSE	LIG_APCC_ABBA_1	0.0833
p.L383Q	DO23678	LUAD	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.0833
p.D392Y	TCGA-A5-A0G1	UCEC	TCGA	MSVYSE	LIG_APCC_ABBA_1	0.7325
p.D392Y	DO42472	UCEC	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.7325
p.K394T	TCGA-A5-A0G1	UCEC	TCGA	MSVYSE	LIG_APCC_ABBA_1	0.7306
p.K394T	DO42472	UCEC	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.7306
p.G382D	TCGA-AX-A0J1	UCEC	TCGA	MSVYSE	LIG_APCC_ABBA_1	0.0556
p.G382D	DO41199	UCEC	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.0556
p.T407N	TCGA-AX-A1CE	UCEC	TCGA	MSVYSE	LIG_APCC_ABBA_1	0.0556
p.T407N	DO42280	UCEC	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.0556
p.S390G	DO48457	BLCA	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.2778
p.V394I	DO9346	COAD	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.5965
p.D404H	DO233025	GACA	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.1389
p.N389K	DO12100	GBM	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.25
p.S386I	DO15014	HNSC	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.1667
p.G390V	DO229036	LICA	ICGC	MSVYSE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDW5	Synaptotagmin-like protein 5	LIG_APCC_ABBA_1	392:397	MSVYSE	APC,CDC20,FZR1	0.5661	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons