DegronMD - Q8TDW5(SYTL5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L383I	TCGA-06-5416	GBM	TCGA	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.L383I	TCGA-69-7980	LUAD	TCGA	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.L383I	DO10880	GBM	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.L383I	DO23678	LUAD	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.L383Q	TCGA-69-7980	LUAD	TCGA	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.L383Q	DO23678	LUAD	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.D392Y	TCGA-A5-A0G1	UCEC	TCGA	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.7325
p.D392Y	DO42472	UCEC	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.7325
p.K394T	TCGA-A5-A0G1	UCEC	TCGA	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.7306
p.K394T	DO42472	UCEC	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.7306
p.R252W	TCGA-AX-A05Z	UCEC	TCGA	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.R252W	TCGA-S5-A6DX	BLCA	TCGA	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.R252W	DO51903	BLCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.R252W	DO225194	BRCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.R252W	DO52561	BRCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.R252W	DO40884	UCEC	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.G382D	TCGA-AX-A0J1	UCEC	TCGA	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0556
p.G382D	DO41199	UCEC	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0556
p.T407N	TCGA-AX-A1CE	UCEC	TCGA	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0556
p.T407N	DO42280	UCEC	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0556
p.E242K	TCGA-DK-AA77	BLCA	TCGA	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.25
p.E242K	DO48366	BLCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.25
p.E242K	DO219014	BLCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.25
p.D240Y	TCGA-FI-A2EW	UCEC	TCGA	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.1944
p.D240Y	DO41500	UCEC	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.1944
p.G259D	TCGA-VQ-A8P2	STAD	TCGA	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.1111
p.G259D	DO51761	STAD	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.1111
p.S390G	DO48457	BLCA	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.2778
p.P258S	DO223491	CLLE	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.1389
p.V394I	DO9346	COAD	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.5965
p.D404H	DO233025	GACA	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.1389
p.N389K	DO12100	GBM	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.25
p.S386I	DO15014	HNSC	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.1667
p.G259C	DO228971	LICA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.1111
p.G259V	DO228971	LICA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.1111
p.P248R	DO232019	LICA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.7512
p.G390V	DO229036	LICA	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.2778
p.S250C	DO221118	MALY	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.643
p.T257N	DO229213	THCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.1667
p.K249T	SIDM00888	Other Solid Cancers	GDSC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.6195
p.K249T	ACH-000055	Brain Cancer	CCLE	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.6195
p.K249T	D-283MED	central nervous system	COSMIC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.6195
p.P245S	SIDM00299	Other Sarcomas	GDSC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.6752
p.P245S	ACH-002271	Sarcoma	CCLE	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYTL5

UniProt ID: Q8TDW5

Entrez ID: 94122

Protein name: Synaptotagmin-like protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYTL5 in