DegronMD - Q8TDW5(SYTL5)

FUNCTION: May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.

GO - Biological processes (BP): exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]

GO - Molecular function (MF): metal ion binding [GO:0046872]; neurexin family protein binding [GO:0042043]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]

GO - Cellular component (CC): exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P248R	DO232019	LICA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.7512
p.D392Y	TCGA-A5-A0G1	UCEC	TCGA	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.7325
p.D392Y	DO42472	UCEC	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.7325
p.K394T	TCGA-A5-A0G1	UCEC	TCGA	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.7306
p.K394T	DO42472	UCEC	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.7306
p.P245S	SIDM00299	Other Sarcomas	GDSC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.6752
p.P245S	ACH-002271	Sarcoma	CCLE	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.6752
p.S250C	DO221118	MALY	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.643
p.K249T	SIDM00888	Other Solid Cancers	GDSC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.6195
p.K249T	ACH-000055	Brain Cancer	CCLE	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.6195
p.K249T	D-283MED	central nervous system	COSMIC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation altering degron motif	0.6195
p.V394I	DO9346	COAD	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.5965
p.R252W	TCGA-AX-A05Z	UCEC	TCGA	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.R252W	TCGA-S5-A6DX	BLCA	TCGA	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.R252W	DO51903	BLCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.R252W	DO225194	BRCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.R252W	DO52561	BRCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.R252W	DO40884	UCEC	ICGC	PRTPKSS	DEG_SCF_FBW7_1	245:251	Mutation rewiring degron network	0.3056
p.S390G	DO48457	BLCA	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.2778
p.G390V	DO229036	LICA	ICGC	MSVYSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 44 entries

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Kaplan plot for SYTL5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYTL5

UniProt ID: Q8TDW5

Entrez ID: 94122

Protein name: Synaptotagmin-like protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYTL5 in