DegronMD

Uniprot ID: Q8TDW5

Source protein: Synaptotagmin-like protein 5

Source gene: SYTL5

Class: DEG_SCF_FBW7_1

Location: 245:251

E3 ligase: FBXW7

DEGRON score: 0.9926

ASA_SCORE: 98.9

COIL: 0.9291

CONS_SCORE: 0.4552

DSS_SCORE: 0.8558

HELIX: 0.0381

FCONS_SCORE: 1.1313

RIG_SCORE: 0.5301

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R252W	TCGA-AX-A05Z	UCEC	TCGA	PRTPKSS	DEG_SCF_FBW7_1	0.3056
p.R252W	TCGA-S5-A6DX	BLCA	TCGA	PRTPKSS	DEG_SCF_FBW7_1	0.3056
p.R252W	DO51903	BLCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.3056
p.R252W	DO225194	BRCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.3056
p.R252W	DO52561	BRCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.3056
p.R252W	DO40884	UCEC	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.3056
p.E242K	TCGA-DK-AA77	BLCA	TCGA	PRTPKSS	DEG_SCF_FBW7_1	0.25
p.E242K	DO48366	BLCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.25
p.E242K	DO219014	BLCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.25
p.D240Y	TCGA-FI-A2EW	UCEC	TCGA	PRTPKSS	DEG_SCF_FBW7_1	0.1944
p.D240Y	DO41500	UCEC	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.1944
p.G259D	TCGA-VQ-A8P2	STAD	TCGA	PRTPKSS	DEG_SCF_FBW7_1	0.1111
p.G259D	DO51761	STAD	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.1111
p.P258S	DO223491	CLLE	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.1389
p.G259C	DO228971	LICA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.1111
p.G259V	DO228971	LICA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.1111
p.P248R	DO232019	LICA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.7512
p.S250C	DO221118	MALY	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.643
p.T257N	DO229213	THCA	ICGC	PRTPKSS	DEG_SCF_FBW7_1	0.1667
p.K249T	SIDM00888	Other Solid Cancers	GDSC	PRTPKSS	DEG_SCF_FBW7_1	0.6195
p.K249T	ACH-000055	Brain Cancer	CCLE	PRTPKSS	DEG_SCF_FBW7_1	0.6195
p.K249T	D-283MED	central_nervous_system	COSMIC	PRTPKSS	DEG_SCF_FBW7_1	0.6195
p.P245S	SIDM00299	Other Sarcomas	GDSC	PRTPKSS	DEG_SCF_FBW7_1	0.6752
p.P245S	ACH-002271	Sarcoma	CCLE	PRTPKSS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDW5	Synaptotagmin-like protein 5	DEG_SCF_FBW7_1	245:251	PRTPKSS	FBXW7	0.9926	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons