DegronMD

Uniprot ID: O95155

Source protein: Ubiquitin conjugation factor E4 B

Source gene: UBE4B

Class: DEG_SCF_FBW7_1

Location: 60:65

E3 ligase: FBXW7

DEGRON score: 0.9848

ASA_SCORE: 89.5167

COIL: 0.9568

CONS_SCORE: 0.2557

DSS_SCORE: 0.5659

HELIX: 0.018

FCONS_SCORE: 1.0216

RIG_SCORE: 0.6611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G68D	TCGA-AG-A036	READ	TCGA	MTPATS	DEG_SCF_FBW7_1	0.25
p.L55V	TCGA-BB-A6UO	HNSC	TCGA	MTPATS	DEG_SCF_FBW7_1	0.1944
p.L55V	DO218985	HNSC	ICGC	MTPATS	DEG_SCF_FBW7_1	0.1944
p.P66T	TCGA-D3-A1Q1	SKCM	TCGA	MTPATS	DEG_SCF_FBW7_1	0.3056
p.P66T	DO37445	SKCM	ICGC	MTPATS	DEG_SCF_FBW7_1	0.3056
p.M60V	TCGA-MN-A4N4	LUAD	TCGA	MTPATS	DEG_SCF_FBW7_1	0.6097
p.M60V	DO26250	LUAD	ICGC	MTPATS	DEG_SCF_FBW7_1	0.6097
p.N74S	DO3376	BRCA	ICGC	MTPATS	DEG_SCF_FBW7_1	0.0833
p.S68A	DO52438	COCA	ICGC	MTPATS	DEG_SCF_FBW7_1	0.25
p.M60I	DO228936	LICA	ICGC	MTPATS	DEG_SCF_FBW7_1	0.6507
p.S66F	DO222632	MELA	ICGC	MTPATS	DEG_SCF_FBW7_1	0.3056
p.V61L	DO32247	OV	ICGC	MTPATS	DEG_SCF_FBW7_1	0.6765
p.A69T	DO228138	PBCA	ICGC	MTPATS	DEG_SCF_FBW7_1	0.2222
p.Q70R	DO229216	THCA	ICGC	MTPATS	DEG_SCF_FBW7_1	0.1944
p.N56K	SIDM00941	Kidney Carcinoma	GDSC	MTPATS	DEG_SCF_FBW7_1	0.2222
p.N56K	ACH-000433	Kidney Cancer	CCLE	MTPATS	DEG_SCF_FBW7_1	0.2222
p.N56K	CAKI-1	kidney	COSMIC	MTPATS	DEG_SCF_FBW7_1	0.2222
p.G54A	ACH-000868	Lung Cancer	CCLE	MTPATS	DEG_SCF_FBW7_1	0.1667
p.I74V	ACH-001399	Colon/Colorectal Cancer	CCLE	MTPATS	DEG_SCF_FBW7_1	0.0833
p.I74V	SW626	ovary	COSMIC	MTPATS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95155	Ubiquitin conjugation factor E4 B	DEG_SCF_FBW7_1	60:65	MTPATS	FBXW7	0.9848	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons