DegronMD - O95155(UBE4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R11W	TCGA-AA-3956	COAD	TCGA	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.8634
p.R11W	TCGA-HF-7132	STAD	TCGA	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.8634
p.A357T	TCGA-AF-3400	READ	TCGA	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1389
p.A357T	TCGA-F1-6874	STAD	TCGA	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1389
p.A357T	DO36759	READ	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1389
p.A357T	DO38201	STAD	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1389
p.G68D	TCGA-AG-A036	READ	TCGA	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.25
p.L55V	TCGA-BB-A6UO	HNSC	TCGA	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.1944
p.L55V	DO218985	HNSC	ICGC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.1944
p.R371K	TCGA-BP-5182	KIRC	TCGA	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.25
p.R371K	DO18552	KIRC	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.25
p.A365T	TCGA-CA-6717	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.6028
p.A365T	DO8264	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.6028
p.P66T	TCGA-D3-A1Q1	SKCM	TCGA	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.3056
p.P66T	DO37445	SKCM	ICGC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.3056
p.S368F	TCGA-DK-A1A7	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.7982
p.S368F	DO483	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.7982
p.S368F	DO229381	BTCA	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.7982
p.L14I	TCGA-ER-A19T	SKCM	TCGA	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.7174
p.L14I	DO51251	SKCM	ICGC	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.7174
p.Q361R	TCGA-EY-A1G8	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.25
p.Q361R	DO52479	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.25
p.Q361R	DO43578	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.25
p.M60V	TCGA-MN-A4N4	LUAD	TCGA	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation altering degron motif	0.6097
p.M60V	DO26250	LUAD	ICGC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation altering degron motif	0.6097
p.R16P	TCGA-R6-A6Y0	ESCA	TCGA	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.6401
p.P372L	TCGA-YD-A9TA	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.2222
p.P372L	DO219503	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.2222
p.S38C	DO2401	BRCA	ICGC	PTTPLTS	DEG_SCF_FBW7_1	25:31	Mutation rewiring degron network	0.1389
p.N74S	DO3376	BRCA	ICGC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.0833
p.S68A	DO52438	COCA	ICGC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.25
p.P369S	DO11429	GBM	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.3056
p.G371D	DO22205	LGG	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.25
p.M60I	DO228936	LICA	ICGC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation altering degron motif	0.6507
p.D7Y	DO229018	LICA	ICGC	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation blocking phosphorylation signal	0.6944
p.S359I	DO229034	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1944
p.E8D	DO229036	LICA	ICGC	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.2778
p.R16L	DO229038	LICA	ICGC	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.7316
p.P378H	DO229048	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.0556
p.S66F	DO222632	MELA	ICGC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.3056
p.V61L	DO32247	OV	ICGC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation altering degron motif	0.6765
p.R12W	DO33077	PACA	ICGC	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.7523
p.A69T	DO228138	PBCA	ICGC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.2222
p.P378S	DO232224	PBCA	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.0556
p.S25N	DO50284	SKCM	ICGC	PTTPLTS	DEG_SCF_FBW7_1	25:31	Mutation altering degron motif	0.7069
p.Q70R	DO229216	THCA	ICGC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.1944
p.R378C	DO219773	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.0556
p.N56K	SIDM00941	Kidney Carcinoma	GDSC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.2222
p.N56K	ACH-000433	Kidney Cancer	CCLE	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.2222
p.N56K	CAKI-1	kidney	COSMIC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.2222
p.T22S	SIDM00410	Other Blood Cancers	GDSC	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation blocking phosphorylation signal	0.6667
p.T22S	SIDM00410	Other Blood Cancers	GDSC	PTTPLTS	DEG_SCF_FBW7_1	25:31	Mutation blocking phosphorylation signal	0.6944
p.T22S	ACH-002317	Leukemia	CCLE	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation blocking phosphorylation signal	0.6667
p.T22S	ACH-002317	Leukemia	CCLE	PTTPLTS	DEG_SCF_FBW7_1	25:31	Mutation blocking phosphorylation signal	0.6944
p.T22S	YT	haematopoietic and lymphoid tissue	COSMIC	RRRRLARLA	DEG_APCC_DBOX_1	10:18	Mutation blocking phosphorylation signal	0.6667
p.T22S	YT	haematopoietic and lymphoid tissue	COSMIC	PTTPLTS	DEG_SCF_FBW7_1	25:31	Mutation blocking phosphorylation signal	0.6944
p.L368F	ACH-000783	Breast Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.6981
p.L368F	CAMA-1	breast	COSMIC	PASSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.6981
p.G54A	ACH-000868	Lung Cancer	CCLE	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.1667
p.I74V	ACH-001399	Colon/Colorectal Cancer	CCLE	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.0833
p.I74V	SW626	ovary	COSMIC	MTPATS	DEG_SCF_FBW7_1	60:65	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBE4B

UniProt ID: O95155

Entrez ID: 10277

Protein name: Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBE4B in