DegronMD

Uniprot ID: O95155

Source protein: Ubiquitin conjugation factor E4 B

Source gene: UBE4B

Class: DEG_SCF_FBW7_1

Location: 25:31

E3 ligase: FBXW7

DEGRON score: 0.9626

ASA_SCORE: 97.2143

COIL: 0.967

CONS_SCORE: 0.2102

DSS_SCORE: 0.9004

HELIX: 0.0111

FCONS_SCORE: 0.9003

RIG_SCORE: 0.5928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S38C	DO2401	BRCA	ICGC	PTTPLTS	DEG_SCF_FBW7_1	0.1389
p.S25N	DO50284	SKCM	ICGC	PTTPLTS	DEG_SCF_FBW7_1	0.7069
p.T22S	SIDM00410	Other Blood Cancers	GDSC	PTTPLTS	DEG_SCF_FBW7_1	0.6944
p.T22S	ACH-002317	Leukemia	CCLE	PTTPLTS	DEG_SCF_FBW7_1	0.6944
p.T22S	YT	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPLTS	DEG_SCF_FBW7_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95155	Ubiquitin conjugation factor E4 B	DEG_SCF_FBW7_1	25:31	PTTPLTS	FBXW7	0.9626	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons