DegronMD

Uniprot ID: O95155

Source protein: Ubiquitin conjugation factor E4 B

Source gene: UBE4B

Class: DEG_APCC_DBOX_1

Location: 10:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8671

ASA_SCORE: 90.4333

COIL: 0.1248

CONS_SCORE: 0.2782

DSS_SCORE: 0.658

HELIX: 0.8778

FCONS_SCORE: 1.1156

RIG_SCORE: 0.7262

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R11W	TCGA-AA-3956	COAD	TCGA	RRRRLARLA	DEG_APCC_DBOX_1	0.8634
p.R11W	TCGA-HF-7132	STAD	TCGA	RRRRLARLA	DEG_APCC_DBOX_1	0.8634
p.L14I	TCGA-ER-A19T	SKCM	TCGA	RRRRLARLA	DEG_APCC_DBOX_1	0.7174
p.L14I	DO51251	SKCM	ICGC	RRRRLARLA	DEG_APCC_DBOX_1	0.7174
p.R16P	TCGA-R6-A6Y0	ESCA	TCGA	RRRRLARLA	DEG_APCC_DBOX_1	0.6401
p.D7Y	DO229018	LICA	ICGC	RRRRLARLA	DEG_APCC_DBOX_1	0.6944
p.E8D	DO229036	LICA	ICGC	RRRRLARLA	DEG_APCC_DBOX_1	0.2778
p.R16L	DO229038	LICA	ICGC	RRRRLARLA	DEG_APCC_DBOX_1	0.7316
p.R12W	DO33077	PACA	ICGC	RRRRLARLA	DEG_APCC_DBOX_1	0.7523
p.T22S	SIDM00410	Other Blood Cancers	GDSC	RRRRLARLA	DEG_APCC_DBOX_1	0.6667
p.T22S	ACH-002317	Leukemia	CCLE	RRRRLARLA	DEG_APCC_DBOX_1	0.6667
p.T22S	YT	haematopoietic_and_lymphoid_tissue	COSMIC	RRRRLARLA	DEG_APCC_DBOX_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95155	Ubiquitin conjugation factor E4 B	DEG_APCC_DBOX_1	10:18	RRRRLARLA	APC,CDC20,FZR1	0.8671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons