DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 3221:3226

E3 ligase: FBXW7

DEGRON score: 0.5994

ASA_SCORE: 99.0833

COIL: 0.9207

CONS_SCORE: 0.5236

DSS_SCORE: 0.6416

HELIX: 0.0123

FCONS_SCORE: 0.9593

RIG_SCORE: 0.6735

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3232M	TCGA-09-1664	OV	TCGA	MTPLTS	DEG_SCF_FBW7_1	0.1667
p.T3232M	DO28147	OV	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.1667
p.V3229A	TCGA-28-5204	GBM	TCGA	MTPLTS	DEG_SCF_FBW7_1	0.25
p.V3229A	DO11884	GBM	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.25
p.T3225A	TCGA-56-7730	LUSC	TCGA	MTPLTS	DEG_SCF_FBW7_1	0.6028
p.T3225A	DO26617	LUSC	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.6028
p.E3219K	TCGA-66-2785	LUSC	TCGA	MTPLTS	DEG_SCF_FBW7_1	0.2778
p.E3219K	TCGA-DK-A3X1	BLCA	TCGA	MTPLTS	DEG_SCF_FBW7_1	0.2778
p.E3219K	DO447	BLCA	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.2778
p.E3219K	DO26520	LUSC	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.2778
p.E3219K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	MTPLTS	DEG_SCF_FBW7_1	0.2778
p.E3219K	ACH-000916	Lung Cancer	CCLE	MTPLTS	DEG_SCF_FBW7_1	0.2778
p.E3219K	NCI-H1573	lung	COSMIC	MTPLTS	DEG_SCF_FBW7_1	0.2778
p.P3233S	TCGA-AA-3984	COAD	TCGA	MTPLTS	DEG_SCF_FBW7_1	0.1389
p.P3233S	DO9002	COAD	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.1389
p.P3233L	TCGA-AD-6895	COAD	TCGA	MTPLTS	DEG_SCF_FBW7_1	0.1389
p.P3233L	DO8938	COAD	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.1389
p.T3225I	TCGA-D3-A51R	SKCM	TCGA	MTPLTS	DEG_SCF_FBW7_1	0.5966
p.T3225I	DO47480	SKCM	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.5966
p.T3214A	TCGA-DA-A1HY	SKCM	TCGA	MTPLTS	DEG_SCF_FBW7_1	0.1389
p.T3214A	DO37409	SKCM	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.1389
p.G3220E	TCGA-EE-A2MS	SKCM	TCGA	MTPLTS	DEG_SCF_FBW7_1	0.3056
p.G3220E	DO37567	SKCM	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.3056
p.G3220R	TCGA-QB-A6FS	SKCM	TCGA	MTPLTS	DEG_SCF_FBW7_1	0.3056
p.G3220R	DO48654	SKCM	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.3056
p.V3227I	DO222480	COCA	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.3056
p.V3227I	DO222588	COCA	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.3056
p.V3227I	DO229004	LICA	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.3056
p.I3212M	DO229030	LICA	ICGC	MTPLTS	DEG_SCF_FBW7_1	0.0833
p.P3223L	ACH-002005	Skin Cancer	CCLE	MTPLTS	DEG_SCF_FBW7_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTPLTS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of MTPLTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3221:3226	MTPLTS	FBXW7	0.5994	More...