DegronMD

Uniprot ID: Q8N9W5

Source protein: Dynein axonemal assembly factor 3

Source gene: DNAAF3

Class: DEG_SCF_FBW7_1

Location: 1:7

E3 ligase: FBXW7

DEGRON score: 0.8391

ASA_SCORE: 76.7714

COIL: 0.8009

CONS_SCORE: 0.3801

DSS_SCORE: 0.8182

HELIX: 0.0514

FCONS_SCORE: 0.6942

RIG_SCORE: 0.6618

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L14P	DO220826	BRCA	ICGC	MTTPAGS	DEG_SCF_FBW7_1	0.1389
p.S7C	DO48982	CESC	ICGC	MTTPAGS	DEG_SCF_FBW7_1	0.7541
p.P4T	DO14662	HNSC	ICGC	MTTPAGS	DEG_SCF_FBW7_1	0.7031
p.P4T	DO229029	LICA	ICGC	MTTPAGS	DEG_SCF_FBW7_1	0.7031
p.E13G	DO228531	LICA	ICGC	MTTPAGS	DEG_SCF_FBW7_1	0.1667
p.S16R	DO228948	LICA	ICGC	MTTPAGS	DEG_SCF_FBW7_1	0.0833
p.A11E	DO229028	LICA	ICGC	MTTPAGS	DEG_SCF_FBW7_1	0.2222
p.P8L	DO222775	MELA	ICGC	MTTPAGS	DEG_SCF_FBW7_1	0.3056
p.P8L	DO47665	SKCM	ICGC	MTTPAGS	DEG_SCF_FBW7_1	0.3056
p.P8L	SIDM00189	Melanoma	GDSC	MTTPAGS	DEG_SCF_FBW7_1	0.3056
p.P8L	CP67-MEL	skin	COSMIC	MTTPAGS	DEG_SCF_FBW7_1	0.3056
p.L11S	DO48032	STAD	ICGC	MTTPAGS	DEG_SCF_FBW7_1	0.2222
p.S10P	DO42673	UCEC	ICGC	MTTPAGS	DEG_SCF_FBW7_1	0.25
p.A11T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	MTTPAGS	DEG_SCF_FBW7_1	0.2222
p.A11T	ACH-000953	Leukemia	CCLE	MTTPAGS	DEG_SCF_FBW7_1	0.2222
p.A11T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	MTTPAGS	DEG_SCF_FBW7_1	0.2222
p.E13K	SIDM01228	Melanoma	GDSC	MTTPAGS	DEG_SCF_FBW7_1	0.1667
p.E13K	CHL-1	skin	COSMIC	MTTPAGS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9W5	Dynein axonemal assembly factor 3	DEG_SCF_FBW7_1	1:7	MTTPAGS	FBXW7	0.8391	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons