DegronMD

Uniprot ID: P52294

Source protein: Importin subunit alpha-5

Source gene: KPNA1

Class: DEG_SCF_FBW7_2

Location: 1:7

E3 ligase: FBXW7

DEGRON score: 0.8142

ASA_SCORE: 99.6

COIL: 0.8371

CONS_SCORE: 0.3167

DSS_SCORE: 0.8843

HELIX: 0.1631

FCONS_SCORE: 0.6977

RIG_SCORE: 0.673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R10C	TCGA-AA-3984	COAD	TCGA	MTTPGKE	DEG_SCF_FBW7_2	0.25
p.R10C	DO9002	COAD	ICGC	MTTPGKE	DEG_SCF_FBW7_2	0.25
p.E7D	TCGA-AP-A1E0	UCEC	TCGA	MTTPGKE	DEG_SCF_FBW7_2	0.6758
p.E7D	TCGA-E6-A1LX	UCEC	TCGA	MTTPGKE	DEG_SCF_FBW7_2	0.6758
p.E7D	TCGA-EO-A3B0	UCEC	TCGA	MTTPGKE	DEG_SCF_FBW7_2	0.6758
p.E7D	DO219773	UCEC	ICGC	MTTPGKE	DEG_SCF_FBW7_2	0.6758
p.E7D	DO41020	UCEC	ICGC	MTTPGKE	DEG_SCF_FBW7_2	0.6758
p.E7D	DO43154	UCEC	ICGC	MTTPGKE	DEG_SCF_FBW7_2	0.6758
p.G5E	TCGA-AX-A2HC	UCEC	TCGA	MTTPGKE	DEG_SCF_FBW7_2	0.6087
p.G5E	DO41572	UCEC	ICGC	MTTPGKE	DEG_SCF_FBW7_2	0.6087
p.G5R	TCGA-GU-A766	BLCA	TCGA	MTTPGKE	DEG_SCF_FBW7_2	0.6457
p.G5R	DO51891	BLCA	ICGC	MTTPGKE	DEG_SCF_FBW7_2	0.6457
p.N16K	DO229018	LICA	ICGC	MTTPGKE	DEG_SCF_FBW7_2	0.0833
p.K12Q	SIDM00145	T-Lymphoblastic Leukemia	GDSC	MTTPGKE	DEG_SCF_FBW7_2	0.3056
p.K12Q	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	MTTPGKE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52294	Importin subunit alpha-5	DEG_SCF_FBW7_2	1:7	MTTPGKE	FBXW7	0.8142	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons