DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MTTPNKT
Uniprot ID:
Q9UM13
Source protein:
Anaphase-promoting complex subunit 10
Source gene:
ANAPC10
Class:
DEG_SCF_FBW7_1
Location:
1:7
E3 ligase:
FBXW7
DEGRON score:
0.9673
ASA_SCORE:
110.6571
COIL:
0.9699
CONS_SCORE:
0.2947
DSS_SCORE:
0.9612
HELIX:
0.0094
FCONS_SCORE:
0.8945
RIG_SCORE:
0.6328
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ANAPC10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MTTPNKT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UM13
Anaphase-promoting complex subunit 10
DEG_SCF_FBW7_1
1:7
MTTPNKT
FBXW7
0.9673
More...