DegronMD

Uniprot ID: P11836

Source protein: B-lymphocyte antigen CD20

Source gene: MS4A1

Class: DEG_SCF_FBW7_1

Location: 1:7

E3 ligase: FBXW7

DEGRON score: 0.5993

ASA_SCORE: 101.0714

COIL: 0.9527

CONS_SCORE: 0.5281

DSS_SCORE: 0.8798

HELIX: 0.0164

FCONS_SCORE: 0.9847

RIG_SCORE: 0.6722

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2K	TCGA-13-0726	OV	TCGA	MTTPRNS	DEG_SCF_FBW7_1	0.7306
p.T2K	DO28373	OV	ICGC	MTTPRNS	DEG_SCF_FBW7_1	0.7306
p.T11N	TCGA-44-2657	LUAD	TCGA	MTTPRNS	DEG_SCF_FBW7_1	0.6667
p.T11N	TCGA-F5-6814	READ	TCGA	MTTPRNS	DEG_SCF_FBW7_1	0.6667
p.T11N	DO25020	LUAD	ICGC	MTTPRNS	DEG_SCF_FBW7_1	0.6667
p.T11N	DO36556	READ	ICGC	MTTPRNS	DEG_SCF_FBW7_1	0.6667
p.E15K	TCGA-66-2773	LUSC	TCGA	MTTPRNS	DEG_SCF_FBW7_1	0.1111
p.E15K	DO26536	LUSC	ICGC	MTTPRNS	DEG_SCF_FBW7_1	0.1111
p.N6I	TCGA-94-8491	LUSC	TCGA	MTTPRNS	DEG_SCF_FBW7_1	0.6169
p.N6I	DO219174	LUSC	ICGC	MTTPRNS	DEG_SCF_FBW7_1	0.6169
p.G10W	TCGA-D3-A2JD	SKCM	TCGA	MTTPRNS	DEG_SCF_FBW7_1	0.25
p.G10W	DO37543	SKCM	ICGC	MTTPRNS	DEG_SCF_FBW7_1	0.25
p.G10R	TCGA-DK-A1A3	BLCA	TCGA	MTTPRNS	DEG_SCF_FBW7_1	0.25
p.G10R	DO558	BLCA	ICGC	MTTPRNS	DEG_SCF_FBW7_1	0.25
p.P13L	DO233271	GACA	ICGC	MTTPRNS	DEG_SCF_FBW7_1	0.1667
p.P13L	SIDM00845	Burkitt's Lymphoma	GDSC	MTTPRNS	DEG_SCF_FBW7_1	0.1667
p.P13L	SIDM00154	Mesothelioma	GDSC	MTTPRNS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11836	B-lymphocyte antigen CD20	DEG_SCF_FBW7_1	1:7	MTTPRNS	FBXW7	0.5993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons