DegronMD

Uniprot ID: P21333

Source protein: Filamin-A

Source gene: FLNA

Class: LIG_APCC_ABBA_1

Location: 849:854

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5498

ASA_SCORE: 49.8

COIL: 0.342

CONS_SCORE: 0.3276

DSS_SCORE: 0.3115

HELIX: 0.0022

FCONS_SCORE: 0.9124

RIG_SCORE: 0.8942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T859N	TCGA-61-2000	OV	TCGA	MVLFAD	LIG_APCC_ABBA_1	0.6389
p.T859N	DO29940	OV	ICGC	MVLFAD	LIG_APCC_ABBA_1	0.6389
p.I848S	TCGA-AP-A0LM	UCEC	TCGA	MVLFAD	LIG_APCC_ABBA_1	0.3056
p.I848S	DO43306	UCEC	ICGC	MVLFAD	LIG_APCC_ABBA_1	0.3056
p.T839M	TCGA-DJ-A3UM	THCA	TCGA	MVLFAD	LIG_APCC_ABBA_1	0.0556
p.T839M	TCGA-EA-A410	CESC	TCGA	MVLFAD	LIG_APCC_ABBA_1	0.0556
p.T839M	DO222955	BTCA	ICGC	MVLFAD	LIG_APCC_ABBA_1	0.0556
p.T839M	DO49929	CESC	ICGC	MVLFAD	LIG_APCC_ABBA_1	0.0556
p.T839M	DO39014	THCA	ICGC	MVLFAD	LIG_APCC_ABBA_1	0.0556
p.T857M	TCGA-ND-A4WA	UCS	TCGA	MVLFAD	LIG_APCC_ABBA_1	0.25
p.R863Q	DO228783	GACA	ICGC	MVLFAD	LIG_APCC_ABBA_1	0.0833
p.P861T	DO229024	LICA	ICGC	MVLFAD	LIG_APCC_ABBA_1	0.1389
p.A843T	DO50970	LICA	ICGC	MVLFAD	LIG_APCC_ABBA_1	0.1667
p.G844V	DO229211	THCA	ICGC	MVLFAD	LIG_APCC_ABBA_1	0.1944
p.T847I	DO43218	UCEC	ICGC	MVLFAD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21333	Filamin-A	LIG_APCC_ABBA_1	849:854	MVLFAD	APC,CDC20,FZR1	0.5498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons