DegronMD - P21333(FLNA)

GO - Biological processes (BP): actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; angiogenesis [GO:0001525]; blood coagulation, intrinsic pathway [GO:0007597]; blood vessel remodeling [GO:0001974]; cell-cell junction organization [GO:0045216]; cilium assembly [GO:0060271]; cytoplasmic sequestering of protein [GO:0051220]; early endosome to late endosome transport [GO:0045022]; epithelial to mesenchymal transition [GO:0001837]; establishment of protein localization [GO:0045184]; heart morphogenesis [GO:0003007]; megakaryocyte development [GO:0035855]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase I [GO:0016479]; platelet aggregation [GO:0070527]; positive regulation of axon regeneration [GO:0048680]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of platelet activation [GO:0010572]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to cell surface [GO:0034394]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell migration [GO:0030334]; regulation of membrane repolarization during atrial cardiac muscle cell action potential [GO:1905000]; regulation of membrane repolarization during cardiac muscle cell action potential [GO:1905031]; release of sequestered calcium ion into cytosol [GO:0051209]; semaphorin-plexin signaling pathway [GO:0071526]; synapse organization [GO:0050808]; tubulin deacetylation [GO:0090042]; wound healing, spreading of cells [GO:0044319] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1697E	TCGA-43-2576	LUSC	TCGA	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.25
p.A1607D	TCGA-55-8510	LUAD	TCGA	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation altering degron motif	0.6682
p.A1607D	DO24339	LUAD	ICGC	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation altering degron motif	0.6682
p.T859N	TCGA-61-2000	OV	TCGA	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation blocking phosphorylation signal	0.6389
p.T859N	DO29940	OV	ICGC	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation blocking phosphorylation signal	0.6389
p.I848S	TCGA-AP-A0LM	UCEC	TCGA	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.3056
p.I848S	DO43306	UCEC	ICGC	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.3056
p.D1699E	TCGA-CG-4442	STAD	TCGA	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.1944
p.D1314N	TCGA-D1-A103	UCEC	TCGA	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.1944
p.D1314N	DO42312	UCEC	ICGC	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.1944
p.T1690M	TCGA-D5-6538	COAD	TCGA	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation altering degron motif	0.7423
p.D1601N	TCGA-DD-AADF	LIHC	TCGA	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation rewiring degron network	0.2778
p.D1601N	DO52232	LIHC	ICGC	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation rewiring degron network	0.2778
p.T839M	TCGA-DJ-A3UM	THCA	TCGA	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.0556
p.T839M	TCGA-EA-A410	CESC	TCGA	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.0556
p.T839M	DO222955	BTCA	ICGC	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.0556
p.T839M	DO49929	CESC	ICGC	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.0556
p.T839M	DO39014	THCA	ICGC	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.0556
p.G1315D	TCGA-E6-A1LX	UCEC	TCGA	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.2222
p.G1315D	DO41020	UCEC	ICGC	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.2222
p.T1685M	TCGA-EE-A2MD	SKCM	TCGA	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.25
p.A1678V	TCGA-FI-A2D0	UCEC	TCGA	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.0556
p.T857M	TCGA-ND-A4WA	UCS	TCGA	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.25
p.P1323T	TCGA-X6-A7WB	SARC	TCGA	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation altering degron motif	0.7031
p.P1323T	DO220314	SARC	ICGC	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation altering degron motif	0.7031
p.T1682M	DO7784	COAD	ICGC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.1667
p.G1602S	DO230343	COCA	ICGC	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation rewiring degron network	0.3056
p.R863Q	DO228783	GACA	ICGC	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.0833
p.P1610T	DO229018	LICA	ICGC	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation altering degron motif	0.7031
p.P861T	DO229024	LICA	ICGC	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.1389
p.A843T	DO50970	LICA	ICGC	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.1667
p.D1689E	DO27005	LUSC	ICGC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation altering degron motif	0.6758
p.V1688L	DO46581	OV	ICGC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation altering degron motif	0.5654
p.Y1704C	DO32753	PAAD	ICGC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.0556
p.D1691E	DO38380	STAD	ICGC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation altering degron motif	0.6758
p.G844V	DO229211	THCA	ICGC	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.1944
p.D1701N	DO219773	UCEC	ICGC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.1389
p.D1701N	ACH-000998	Colon/Colorectal Cancer	CCLE	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.1389
p.D1701N	CW-2	large intestine	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.1389
p.T847I	DO43218	UCEC	ICGC	MVLFAD	LIG_APCC_ABBA_1	849:854	Mutation rewiring degron network	0.2778
p.T1594K	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation blocking phosphorylation signal	0.5278
p.T1594K	ACH-000777	Esophageal Cancer	CCLE	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation blocking phosphorylation signal	0.5278
p.M1316T	SIDM00572	Gastric Carcinoma	GDSC	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.25
p.M1316T	SIDM01653	Non-Cancerous	GDSC	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.25
p.M1316T	SIDM00207	Glioblastoma	GDSC	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.25
p.M1316T	SIDM01336	Glioblastoma	GDSC	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.25
p.M1316T	ACH-000368	Brain Cancer	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.25
p.M1316T	ACH-000911	Gastric Cancer	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.25
p.M1316T	ACH-002230	Brain Cancer	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.25
p.M1316T	ACH-002351	Non-Cancerous	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.25
p.D1311G	SIDM00537	Colorectal Carcinoma	GDSC	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.1111
p.D1311G	ACH-000982	Colon/Colorectal Cancer	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.1111
p.D1311G	ACH-001345	Colon/Colorectal Cancer	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.1111
p.D1311G	GP5d	large intestine	COSMIC	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.1111
p.D1692H	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation altering degron motif	0.6577
p.D1692H	KYSE-450	oesophagus	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation altering degron motif	0.6577
p.T1603M	SIDM01609	Endometrial Carcinoma	GDSC	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation altering degron motif	0.8534
p.T1603M	ACH-000972	Endometrial/Uterine Cancer	CCLE	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation altering degron motif	0.8534
p.D1684H	ACH-000865	Esophageal Cancer	CCLE	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.2222
p.D1684H	KYSE-450	oesophagus	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.2222
p.F1703S	ACH-000982	Colon/Colorectal Cancer	CCLE	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.0833
p.F1703S	ACH-001345	Colon/Colorectal Cancer	CCLE	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.0833
p.F1703S	GP5d	large intestine	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.0833
p.Q1310R	ACH-001301	Neuroblastoma	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	1319:1326	Mutation rewiring degron network	0.0833
p.R1606H	EFO-21	ovary	COSMIC	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation altering degron motif	0.8244
p.R1606P	CTV-1	haematopoietic and lymphoid tissue	COSMIC	TYTVAYVPDV	DEG_COP1_1	1603:1612	Mutation altering degron motif	0.7512
p.F1684S	GP5d	large intestine	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.2222
p.D1682N	CW-2	large intestine	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.1667
p.A1687T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	1688:1694	Mutation rewiring degron network	0.3056

Kaplan plot for FLNA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FLNA

UniProt ID: P21333

Entrez ID: 2316

Protein name: Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FLNA in