DegronMD

Uniprot ID: P21333

Source protein: Filamin-A

Source gene: FLNA

Class: DEG_SCF_FBW7_2

Location: 1319:1326

E3 ligase: FBXW7

DEGRON score: 0.9281

ASA_SCORE: 66.275

COIL: 0.4774

CONS_SCORE: 0.6063

DSS_SCORE: 0.4219

HELIX: 0.0016

FCONS_SCORE: 1.1049

RIG_SCORE: 0.7935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1314N	TCGA-D1-A103	UCEC	TCGA	VEYTPYEE	DEG_SCF_FBW7_2	0.1944
p.D1314N	DO42312	UCEC	ICGC	VEYTPYEE	DEG_SCF_FBW7_2	0.1944
p.G1315D	TCGA-E6-A1LX	UCEC	TCGA	VEYTPYEE	DEG_SCF_FBW7_2	0.2222
p.G1315D	DO41020	UCEC	ICGC	VEYTPYEE	DEG_SCF_FBW7_2	0.2222
p.P1323T	TCGA-X6-A7WB	SARC	TCGA	VEYTPYEE	DEG_SCF_FBW7_2	0.7031
p.P1323T	DO220314	SARC	ICGC	VEYTPYEE	DEG_SCF_FBW7_2	0.7031
p.M1316T	SIDM00572	Gastric Carcinoma	GDSC	VEYTPYEE	DEG_SCF_FBW7_2	0.25
p.M1316T	SIDM01653	Non-Cancerous	GDSC	VEYTPYEE	DEG_SCF_FBW7_2	0.25
p.M1316T	SIDM00207	Glioblastoma	GDSC	VEYTPYEE	DEG_SCF_FBW7_2	0.25
p.M1316T	SIDM01336	Glioblastoma	GDSC	VEYTPYEE	DEG_SCF_FBW7_2	0.25
p.M1316T	ACH-000368	Brain Cancer	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	0.25
p.M1316T	ACH-000911	Gastric Cancer	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	0.25
p.M1316T	ACH-002230	Brain Cancer	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	0.25
p.M1316T	ACH-002351	Non-Cancerous	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	0.25
p.D1311G	SIDM00537	Colorectal Carcinoma	GDSC	VEYTPYEE	DEG_SCF_FBW7_2	0.1111
p.D1311G	ACH-000982	Colon/Colorectal Cancer	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	0.1111
p.D1311G	ACH-001345	Colon/Colorectal Cancer	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	0.1111
p.D1311G	GP5d	large_intestine	COSMIC	VEYTPYEE	DEG_SCF_FBW7_2	0.1111
p.Q1310R	ACH-001301	Neuroblastoma	CCLE	VEYTPYEE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21333	Filamin-A	DEG_SCF_FBW7_2	1319:1326	VEYTPYEE	FBXW7	0.9281	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons