DegronMD

Uniprot ID: P21333

Source protein: Filamin-A

Source gene: FLNA

Class: DEG_COP1_1

Location: 1603:1612

E3 ligase: COP1

DEGRON score: 0.6059

ASA_SCORE: 35.7

COIL: 0.3331

CONS_SCORE: 0.6206

DSS_SCORE: 0.2701

HELIX: 0.0039

FCONS_SCORE: 1.117

RIG_SCORE: 0.8563

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1607D	TCGA-55-8510	LUAD	TCGA	TYTVAYVPDV	DEG_COP1_1	0.6682
p.A1607D	DO24339	LUAD	ICGC	TYTVAYVPDV	DEG_COP1_1	0.6682
p.D1601N	TCGA-DD-AADF	LIHC	TCGA	TYTVAYVPDV	DEG_COP1_1	0.2778
p.D1601N	DO52232	LIHC	ICGC	TYTVAYVPDV	DEG_COP1_1	0.2778
p.G1602S	DO230343	COCA	ICGC	TYTVAYVPDV	DEG_COP1_1	0.3056
p.P1610T	DO229018	LICA	ICGC	TYTVAYVPDV	DEG_COP1_1	0.7031
p.T1594K	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	TYTVAYVPDV	DEG_COP1_1	0.5278
p.T1594K	ACH-000777	Esophageal Cancer	CCLE	TYTVAYVPDV	DEG_COP1_1	0.5278
p.T1603M	SIDM01609	Endometrial Carcinoma	GDSC	TYTVAYVPDV	DEG_COP1_1	0.8534
p.T1603M	ACH-000972	Endometrial/Uterine Cancer	CCLE	TYTVAYVPDV	DEG_COP1_1	0.8534
p.R1606H	EFO-21	ovary	COSMIC	TYTVAYVPDV	DEG_COP1_1	0.8244
p.R1606P	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	TYTVAYVPDV	DEG_COP1_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21333	Filamin-A	DEG_COP1_1	1603:1612	TYTVAYVPDV	COP1	0.6059	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons