DegronMD

Uniprot ID: P21333

Source protein: Filamin-A

Source gene: FLNA

Class: DEG_SCF_FBW7_1

Location: 1688:1694

E3 ligase: FBXW7

DEGRON score: 0.889

ASA_SCORE: 51.2286

COIL: 0.6779

CONS_SCORE: 0.4853

DSS_SCORE: 0.2702

HELIX: 0.0049

FCONS_SCORE: 0.9623

RIG_SCORE: 0.7946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1697E	TCGA-43-2576	LUSC	TCGA	VCTPDGS	DEG_SCF_FBW7_1	0.25
p.D1699E	TCGA-CG-4442	STAD	TCGA	VCTPDGS	DEG_SCF_FBW7_1	0.1944
p.T1690M	TCGA-D5-6538	COAD	TCGA	VCTPDGS	DEG_SCF_FBW7_1	0.7423
p.T1685M	TCGA-EE-A2MD	SKCM	TCGA	VCTPDGS	DEG_SCF_FBW7_1	0.25
p.A1678V	TCGA-FI-A2D0	UCEC	TCGA	VCTPDGS	DEG_SCF_FBW7_1	0.0556
p.T1682M	DO7784	COAD	ICGC	VCTPDGS	DEG_SCF_FBW7_1	0.1667
p.D1689E	DO27005	LUSC	ICGC	VCTPDGS	DEG_SCF_FBW7_1	0.6758
p.V1688L	DO46581	OV	ICGC	VCTPDGS	DEG_SCF_FBW7_1	0.5654
p.Y1704C	DO32753	PAAD	ICGC	VCTPDGS	DEG_SCF_FBW7_1	0.0556
p.D1691E	DO38380	STAD	ICGC	VCTPDGS	DEG_SCF_FBW7_1	0.6758
p.D1701N	DO219773	UCEC	ICGC	VCTPDGS	DEG_SCF_FBW7_1	0.1389
p.D1701N	ACH-000998	Colon/Colorectal Cancer	CCLE	VCTPDGS	DEG_SCF_FBW7_1	0.1389
p.D1701N	CW-2	large_intestine	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	0.1389
p.D1692H	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VCTPDGS	DEG_SCF_FBW7_1	0.6577
p.D1692H	KYSE-450	oesophagus	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	0.6577
p.D1684H	ACH-000865	Esophageal Cancer	CCLE	VCTPDGS	DEG_SCF_FBW7_1	0.2222
p.D1684H	KYSE-450	oesophagus	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	0.2222
p.F1703S	ACH-000982	Colon/Colorectal Cancer	CCLE	VCTPDGS	DEG_SCF_FBW7_1	0.0833
p.F1703S	ACH-001345	Colon/Colorectal Cancer	CCLE	VCTPDGS	DEG_SCF_FBW7_1	0.0833
p.F1703S	GP5d	large_intestine	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	0.0833
p.F1684S	GP5d	large_intestine	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	0.2222
p.D1682N	CW-2	large_intestine	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	0.1667
p.A1687T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VCTPDGS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21333	Filamin-A	DEG_SCF_FBW7_1	1688:1694	VCTPDGS	FBXW7	0.889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons