DegronMD

Uniprot ID: Q12934

Source protein: Filensin

Source gene: BFSP1

Class: DEG_SCF_FBW7_2

Location: 575:581

E3 ligase: FBXW7

DEGRON score: 0.9826

ASA_SCORE: 85.0571

COIL: 0.9394

CONS_SCORE: 0.4318

DSS_SCORE: 0.7548

HELIX: 0.0206

FCONS_SCORE: 1.1333

RIG_SCORE: 0.5894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E567K	TCGA-24-2281	OV	TCGA	MVTPGAE	DEG_SCF_FBW7_2	0.1111
p.E567K	TCGA-2W-A8YY	CESC	TCGA	MVTPGAE	DEG_SCF_FBW7_2	0.1111
p.E567K	TCGA-AG-A023	READ	TCGA	MVTPGAE	DEG_SCF_FBW7_2	0.1111
p.E567K	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	MVTPGAE	DEG_SCF_FBW7_2	0.1111
p.E567K	ACH-000603	Lung Cancer	CCLE	MVTPGAE	DEG_SCF_FBW7_2	0.1111
p.E567K	BEN	lung	COSMIC	MVTPGAE	DEG_SCF_FBW7_2	0.1111
p.P583T	TCGA-97-7546	LUAD	TCGA	MVTPGAE	DEG_SCF_FBW7_2	0.2778
p.E581D	TCGA-AG-A002	READ	TCGA	MVTPGAE	DEG_SCF_FBW7_2	0.6758
p.R565W	TCGA-AJ-A2QN	UCEC	TCGA	MVTPGAE	DEG_SCF_FBW7_2	0.0556
p.R565W	SIDM02067	Colorectal Carcinoma	GDSC	MVTPGAE	DEG_SCF_FBW7_2	0.0556
p.P589R	TCGA-BH-A18R	BRCA	TCGA	MVTPGAE	DEG_SCF_FBW7_2	0.1111
p.G579S	TCGA-EO-A3AY	UCEC	TCGA	MVTPGAE	DEG_SCF_FBW7_2	0.5882
p.P586S	SIDM00387	Neuroblastoma	GDSC	MVTPGAE	DEG_SCF_FBW7_2	0.1944
p.P586S	ACH-000078	Neuroblastoma	CCLE	MVTPGAE	DEG_SCF_FBW7_2	0.1944
p.P586S	MHH-NB-11	autonomic_ganglia	COSMIC	MVTPGAE	DEG_SCF_FBW7_2	0.1944
p.S569A	ACH-001991	Primary	CCLE	MVTPGAE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12934	Filensin	DEG_SCF_FBW7_2	575:581	MVTPGAE	FBXW7	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons