DegronMD - Q12934(BFSP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E567K	TCGA-24-2281	OV	TCGA	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.1111
p.E567K	TCGA-24-2281	OV	TCGA	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.2222
p.E567K	TCGA-2W-A8YY	CESC	TCGA	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.1111
p.E567K	TCGA-2W-A8YY	CESC	TCGA	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.2222
p.E567K	TCGA-AG-A023	READ	TCGA	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.1111
p.E567K	TCGA-AG-A023	READ	TCGA	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.2222
p.E567K	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.1111
p.E567K	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.2222
p.E567K	ACH-000603	Lung Cancer	CCLE	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.1111
p.E567K	ACH-000603	Lung Cancer	CCLE	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.2222
p.E567K	BEN	lung	COSMIC	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.1111
p.E567K	BEN	lung	COSMIC	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.2222
p.P583T	TCGA-97-7546	LUAD	TCGA	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.2778
p.P583T	TCGA-97-7546	LUAD	TCGA	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.2222
p.E581D	TCGA-AG-A002	READ	TCGA	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation altering degron motif	0.6758
p.R565W	TCGA-AJ-A2QN	UCEC	TCGA	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.0556
p.R565W	TCGA-AJ-A2QN	UCEC	TCGA	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.1667
p.R565W	SIDM02067	Colorectal Carcinoma	GDSC	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.0556
p.R565W	SIDM02067	Colorectal Carcinoma	GDSC	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.1667
p.P589R	TCGA-BH-A18R	BRCA	TCGA	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.1111
p.P589R	TCGA-BH-A18R	BRCA	TCGA	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.0556
p.G579S	TCGA-EO-A3AY	UCEC	TCGA	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation altering degron motif	0.5882
p.G579S	TCGA-EO-A3AY	UCEC	TCGA	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation altering degron motif	0.5882
p.P586S	SIDM00387	Neuroblastoma	GDSC	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.1944
p.P586S	SIDM00387	Neuroblastoma	GDSC	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.1389
p.P586S	ACH-000078	Neuroblastoma	CCLE	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.1944
p.P586S	ACH-000078	Neuroblastoma	CCLE	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.1389
p.P586S	MHH-NB-11	autonomic ganglia	COSMIC	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.1944
p.P586S	MHH-NB-11	autonomic ganglia	COSMIC	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.1389
p.S569A	ACH-001991	Primary	CCLE	MVTPGAE	DEG_SCF_FBW7_2	575:581	Mutation rewiring degron network	0.1667
p.S569A	ACH-001991	Primary	CCLE	RPCAMVTPG	DEG_SIAH_1	571:579	Mutation rewiring degron network	0.2778

Kaplan plot for BFSP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BFSP1

UniProt ID: Q12934

Entrez ID: 631

Protein name: Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H) [Cleaved into: Filensin C-terminal fragment; Filensin N-terminal fragment]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BFSP1 in