DegronMD

Uniprot ID: Q12934

Source protein: Filensin

Source gene: BFSP1

Class: DEG_SIAH_1

Location: 571:579

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9943

ASA_SCORE: 79.7111

COIL: 0.9247

CONS_SCORE: 0.4519

DSS_SCORE: 0.7609

HELIX: 0.0302

FCONS_SCORE: 1.2764

RIG_SCORE: 0.6239

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E567K	TCGA-24-2281	OV	TCGA	RPCAMVTPG	DEG_SIAH_1	0.2222
p.E567K	TCGA-2W-A8YY	CESC	TCGA	RPCAMVTPG	DEG_SIAH_1	0.2222
p.E567K	TCGA-AG-A023	READ	TCGA	RPCAMVTPG	DEG_SIAH_1	0.2222
p.E567K	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	RPCAMVTPG	DEG_SIAH_1	0.2222
p.E567K	ACH-000603	Lung Cancer	CCLE	RPCAMVTPG	DEG_SIAH_1	0.2222
p.E567K	BEN	lung	COSMIC	RPCAMVTPG	DEG_SIAH_1	0.2222
p.P583T	TCGA-97-7546	LUAD	TCGA	RPCAMVTPG	DEG_SIAH_1	0.2222
p.R565W	TCGA-AJ-A2QN	UCEC	TCGA	RPCAMVTPG	DEG_SIAH_1	0.1667
p.R565W	SIDM02067	Colorectal Carcinoma	GDSC	RPCAMVTPG	DEG_SIAH_1	0.1667
p.P589R	TCGA-BH-A18R	BRCA	TCGA	RPCAMVTPG	DEG_SIAH_1	0.0556
p.G579S	TCGA-EO-A3AY	UCEC	TCGA	RPCAMVTPG	DEG_SIAH_1	0.5882
p.P586S	SIDM00387	Neuroblastoma	GDSC	RPCAMVTPG	DEG_SIAH_1	0.1389
p.P586S	ACH-000078	Neuroblastoma	CCLE	RPCAMVTPG	DEG_SIAH_1	0.1389
p.P586S	MHH-NB-11	autonomic_ganglia	COSMIC	RPCAMVTPG	DEG_SIAH_1	0.1389
p.S569A	ACH-001991	Primary	CCLE	RPCAMVTPG	DEG_SIAH_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12934	Filensin	DEG_SIAH_1	571:579	RPCAMVTPG	SIAH1,SIAH2,SIAH3	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons