DegronMD

Uniprot ID: Q9UM11

Source protein: Fizzy-related protein homolog

Source gene: FZR1

Class: CBL_PTK

Location: 143:152

E3 ligase: CBL

DEGRON score: 0.9986

ASA_SCORE: 62.9

COIL: 0.8305

CONS_SCORE: 0.3562

DSS_SCORE: 0.6102

HELIX: 0.0718

FCONS_SCORE: 0.9948

RIG_SCORE: 0.65

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D144N	TCGA-85-A4JB	LUSC	TCGA	NDVSPYSLSP	CBL_PTK	0.5821
p.D144N	TCGA-A5-A0G1	UCEC	TCGA	NDVSPYSLSP	CBL_PTK	0.5821
p.D144N	DO45517	LUSC	ICGC	NDVSPYSLSP	CBL_PTK	0.5821
p.D144N	DO42472	UCEC	ICGC	NDVSPYSLSP	CBL_PTK	0.5821
p.D144N	SIDM00217	Colorectal Carcinoma	GDSC	NDVSPYSLSP	CBL_PTK	0.5821
p.D144N	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	NDVSPYSLSP	CBL_PTK	0.5821
p.D144N	ACH-000264	Lung Cancer	CCLE	NDVSPYSLSP	CBL_PTK	0.5821
p.D144N	ACH-000999	Colon/Colorectal Cancer	CCLE	NDVSPYSLSP	CBL_PTK	0.5821
p.D144N	SNU-1040	large_intestine	COSMIC	NDVSPYSLSP	CBL_PTK	0.5821
p.D144N	Calu-6	lung	COSMIC	NDVSPYSLSP	CBL_PTK	0.5821
p.P152T	TCGA-DK-A3WW	BLCA	TCGA	NDVSPYSLSP	CBL_PTK	0.7031
p.P152T	DO481	BLCA	ICGC	NDVSPYSLSP	CBL_PTK	0.7031
p.D140N	TCGA-DU-6392	LGG	TCGA	NDVSPYSLSP	CBL_PTK	0.25
p.D140N	TCGA-HU-A4GX	STAD	TCGA	NDVSPYSLSP	CBL_PTK	0.25
p.D140N	DO22237	LGG	ICGC	NDVSPYSLSP	CBL_PTK	0.25
p.D140N	DO47757	STAD	ICGC	NDVSPYSLSP	CBL_PTK	0.25
p.R162W	TCGA-DY-A1H8	READ	TCGA	NDVSPYSLSP	CBL_PTK	0.0556
p.R162W	DO37181	READ	ICGC	NDVSPYSLSP	CBL_PTK	0.0556
p.V153I	TCGA-SJ-A6ZI	UCEC	TCGA	NDVSPYSLSP	CBL_PTK	0.3056
p.V153I	DO219784	UCEC	ICGC	NDVSPYSLSP	CBL_PTK	0.3056
p.S137C	TCGA-UY-A78O	BLCA	TCGA	NDVSPYSLSP	CBL_PTK	0.6111
p.S137C	DO219035	BLCA	ICGC	NDVSPYSLSP	CBL_PTK	0.6111
p.C134Y	DO2515	BRCA	ICGC	NDVSPYSLSP	CBL_PTK	0.0833
p.R151W	DO8151	COAD	ICGC	NDVSPYSLSP	CBL_PTK	0.8634
p.K161T	DO233272	GACA	ICGC	NDVSPYSLSP	CBL_PTK	0.0833
p.A156V	DO233898	GACA	ICGC	NDVSPYSLSP	CBL_PTK	0.6667
p.G158V	DO229029	LICA	ICGC	NDVSPYSLSP	CBL_PTK	0.1667
p.V146M	DO229058	LICA	ICGC	NDVSPYSLSP	CBL_PTK	0.7208
p.R136L	DO50889	LICA	ICGC	NDVSPYSLSP	CBL_PTK	0.1389
p.D135N	DO23148	LINC	ICGC	NDVSPYSLSP	CBL_PTK	0.5556
p.K135T	DO46333	OV	ICGC	NDVSPYSLSP	CBL_PTK	0.5556
p.S145F	DO37437	SKCM	ICGC	NDVSPYSLSP	CBL_PTK	0.7982
p.P152L	SIDM00545	Melanoma	GDSC	NDVSPYSLSP	CBL_PTK	0.7582
p.P152L	ACH-000987	Skin Cancer	CCLE	NDVSPYSLSP	CBL_PTK	0.7582
p.P152L	Mewo	skin	COSMIC	NDVSPYSLSP	CBL_PTK	0.7582
p.N155S	SIDM00274	Gastric Carcinoma	GDSC	NDVSPYSLSP	CBL_PTK	0.25
p.N155S	ACH-000047	Gastric Cancer	CCLE	NDVSPYSLSP	CBL_PTK	0.25
p.N155S	GCIY	stomach	COSMIC	NDVSPYSLSP	CBL_PTK	0.25
p.V138M	CS1	bone	COSMIC	NDVSPYSLSP	CBL_PTK	0.6389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NDVSPYSLSP

Degron related mutations and impact score

Drug responses associated with FZR1 mutations

All proteins holding degron of NDVSPYSLSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UM11	Fizzy-related protein homolog	CBL_PTK	143:152	NDVSPYSLSP	CBL	0.9986	More...