DegronMD - Q9UM11(FZR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D144N	TCGA-85-A4JB	LUSC	TCGA	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.5821
p.D144N	TCGA-A5-A0G1	UCEC	TCGA	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.5821
p.D144N	DO45517	LUSC	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.5821
p.D144N	DO42472	UCEC	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.5821
p.D144N	SIDM00217	Colorectal Carcinoma	GDSC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.5821
p.D144N	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.5821
p.D144N	ACH-000264	Lung Cancer	CCLE	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.5821
p.D144N	ACH-000999	Colon/Colorectal Cancer	CCLE	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.5821
p.D144N	SNU-1040	large intestine	COSMIC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.5821
p.D144N	Calu-6	lung	COSMIC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.5821
p.P33L	TCGA-AJ-A3EK	UCEC	TCGA	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.7582
p.P33L	DO41584	UCEC	ICGC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.7582
p.P37T	TCGA-CV-7261	HNSC	TCGA	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.3056
p.P37T	DO15062	HNSC	ICGC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.3056
p.T32M	TCGA-DF-A2KN	UCEC	TCGA	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.8534
p.T32M	DO223282	UCEC	ICGC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.8534
p.P152T	TCGA-DK-A3WW	BLCA	TCGA	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.7031
p.P152T	DO481	BLCA	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.7031
p.D140N	TCGA-DU-6392	LGG	TCGA	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.25
p.D140N	TCGA-HU-A4GX	STAD	TCGA	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.25
p.D140N	DO22237	LGG	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.25
p.D140N	DO47757	STAD	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.25
p.R162W	TCGA-DY-A1H8	READ	TCGA	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.0556
p.R162W	DO37181	READ	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.0556
p.L489H	TCGA-F4-6463	COAD	TCGA	RIR	DEG_APCC_TPR_1	494:496	Mutation rewiring degron network	0.1944
p.P33H	TCGA-HE-7129	KIRP	TCGA	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.7694
p.P33H	DO20786	KIRP	ICGC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.7694
p.R28W	TCGA-KK-A59V	PRAD	TCGA	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.25
p.R28W	DO51346	PRAD	ICGC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.25
p.R28W	SIDM00313	Hodgkin's Lymphoma	GDSC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.25
p.R28W	ACH-000702	Lymphoma	CCLE	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.25
p.R28W	L-1236	haematopoietic and lymphoid tissue	COSMIC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.25
p.V153I	TCGA-SJ-A6ZI	UCEC	TCGA	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.3056
p.V153I	DO219784	UCEC	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.3056
p.S137C	TCGA-UY-A78O	BLCA	TCGA	NDVSPYSLSP	CBL_PTK	143:152	Mutation blocking phosphorylation signal	0.6111
p.S137C	DO219035	BLCA	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation blocking phosphorylation signal	0.6111
p.C134Y	DO2515	BRCA	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.0833
p.R151W	DO8151	COAD	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.8634
p.L31P	DO8858	COAD	ICGC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation altering degron motif	0.6471
p.K161T	DO233272	GACA	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.0833
p.A156V	DO233898	GACA	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation blocking ubiquitination signal	0.6667
p.G158V	DO229029	LICA	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.1667
p.V146M	DO229058	LICA	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.7208
p.R23L	DO229008	LICA	ICGC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1111
p.R136L	DO50889	LICA	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.1389
p.D135N	DO23148	LINC	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation blocking ubiquitination signal	0.5556
p.K135T	DO46333	OV	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation blocking ubiquitination signal	0.5556
p.R23H	DO232761	PBCA	ICGC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1111
p.S145F	DO37437	SKCM	ICGC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.7982
p.P152L	SIDM00545	Melanoma	GDSC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.7582
p.P152L	ACH-000987	Skin Cancer	CCLE	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.7582
p.P152L	Mewo	skin	COSMIC	NDVSPYSLSP	CBL_PTK	143:152	Mutation altering degron motif	0.7582
p.S40L	SIDM00419	Ewing's Sarcoma	GDSC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation blocking phosphorylation signal	0.6667
p.S40L	ACH-000424	Bone Cancer	CCLE	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation blocking phosphorylation signal	0.6667
p.S40L	TC-71	bone	COSMIC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation blocking phosphorylation signal	0.6667
p.R23C	SIDM00522	Small Cell Lung Carcinoma	GDSC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1111
p.R23C	DMS-273	lung	COSMIC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.1111
p.S487F	SIDM00121	T-Lymphoblastic Leukemia	GDSC	RIR	DEG_APCC_TPR_1	494:496	Mutation rewiring degron network	0.1389
p.S487F	ACH-001738	Leukemia	CCLE	RIR	DEG_APCC_TPR_1	494:496	Mutation rewiring degron network	0.1389
p.S487F	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	RIR	DEG_APCC_TPR_1	494:496	Mutation rewiring degron network	0.1389
p.N155S	SIDM00274	Gastric Carcinoma	GDSC	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.25
p.N155S	ACH-000047	Gastric Cancer	CCLE	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.25
p.N155S	GCIY	stomach	COSMIC	NDVSPYSLSP	CBL_PTK	143:152	Mutation rewiring degron network	0.25
p.R29Q	SBC-3	lung	COSMIC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.2778
p.R29Q	OVMIU	ovary	COSMIC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.2778
p.R29Q	HO-1-N-1	salivary gland	COSMIC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.2778
p.R29Q	SCH	stomach	COSMIC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.2778
p.R29Q	HN	upper aerodigestive tract	COSMIC	LTPASS	DEG_SCF_FBW7_1	31:36	Mutation rewiring degron network	0.2778
p.S484F	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	RIR	DEG_APCC_TPR_1	494:496	Mutation rewiring degron network	0.0556
p.V138M	CS1	bone	COSMIC	NDVSPYSLSP	CBL_PTK	143:152	Mutation blocking phosphorylation signal	0.6389

Kaplan plot for FZR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FZR1

UniProt ID: Q9UM11

Entrez ID: 51343

Protein name: Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FZR1 in