DegronMD

Uniprot ID: Q9UM11

Source protein: Fizzy-related protein homolog

Source gene: FZR1

Class: DEG_SCF_FBW7_1

Location: 31:36

E3 ligase: FBXW7

DEGRON score: 0.9905

ASA_SCORE: 94.0167

COIL: 0.9773

CONS_SCORE: 0.2825

DSS_SCORE: 0.6373

HELIX: 0.0108

FCONS_SCORE: 0.7013

RIG_SCORE: 0.6416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P33L	TCGA-AJ-A3EK	UCEC	TCGA	LTPASS	DEG_SCF_FBW7_1	0.7582
p.P33L	DO41584	UCEC	ICGC	LTPASS	DEG_SCF_FBW7_1	0.7582
p.P37T	TCGA-CV-7261	HNSC	TCGA	LTPASS	DEG_SCF_FBW7_1	0.3056
p.P37T	DO15062	HNSC	ICGC	LTPASS	DEG_SCF_FBW7_1	0.3056
p.T32M	TCGA-DF-A2KN	UCEC	TCGA	LTPASS	DEG_SCF_FBW7_1	0.8534
p.T32M	DO223282	UCEC	ICGC	LTPASS	DEG_SCF_FBW7_1	0.8534
p.P33H	TCGA-HE-7129	KIRP	TCGA	LTPASS	DEG_SCF_FBW7_1	0.7694
p.P33H	DO20786	KIRP	ICGC	LTPASS	DEG_SCF_FBW7_1	0.7694
p.R28W	TCGA-KK-A59V	PRAD	TCGA	LTPASS	DEG_SCF_FBW7_1	0.25
p.R28W	DO51346	PRAD	ICGC	LTPASS	DEG_SCF_FBW7_1	0.25
p.R28W	SIDM00313	Hodgkin's Lymphoma	GDSC	LTPASS	DEG_SCF_FBW7_1	0.25
p.R28W	ACH-000702	Lymphoma	CCLE	LTPASS	DEG_SCF_FBW7_1	0.25
p.R28W	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.25
p.L31P	DO8858	COAD	ICGC	LTPASS	DEG_SCF_FBW7_1	0.6471
p.R23L	DO229008	LICA	ICGC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.R23H	DO232761	PBCA	ICGC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.S40L	SIDM00419	Ewing's Sarcoma	GDSC	LTPASS	DEG_SCF_FBW7_1	0.6667
p.S40L	ACH-000424	Bone Cancer	CCLE	LTPASS	DEG_SCF_FBW7_1	0.6667
p.S40L	TC-71	bone	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.6667
p.R23C	SIDM00522	Small Cell Lung Carcinoma	GDSC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.R23C	DMS-273	lung	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.R29Q	SBC-3	lung	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.2778
p.R29Q	OVMIU	ovary	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.2778
p.R29Q	HO-1-N-1	salivary_gland	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.2778
p.R29Q	SCH	stomach	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.2778
p.R29Q	HN	upper_aerodigestive_tract	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	1566:1571	LTPASS	FBXW7	0.6595	More...
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	3123:3128	LTPASS	FBXW7	0.8291	More...
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	4206:4211	LTPASS	FBXW7	0.6169	More...
Q9UM11	Fizzy-related protein homolog	DEG_SCF_FBW7_1	31:36	LTPASS	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons