DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SCF_FBW7_1

Location: 3123:3128

E3 ligase: FBXW7

DEGRON score: 0.8291

ASA_SCORE: 87.8

COIL: 0.9285

CONS_SCORE: 0

DSS_SCORE: 0.6325

HELIX: 0.0163

FCONS_SCORE: 0

RIG_SCORE: 0.6776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3138I	DO224610	LUSC	ICGC	LTPASS	DEG_SCF_FBW7_1	0.0556
p.T3138I	ACH-000467	Colon/Colorectal Cancer	CCLE	LTPASS	DEG_SCF_FBW7_1	0.0556
p.L3119F	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.2222
p.L3119F	HCC1806	breast	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.2222
p.T3124M	NCI-H2110	lung	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.7423
p.T3124M	SiHa	cervix	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.7423
p.T3124M	MOG-G-CCM	central_nervous_system	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.7423
p.T3124M	TOV-21G	ovary	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.7423
p.T3124M	Hep_3B2_1-7	NS	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.7423
p.T3124M	NCI-H835	lung	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.7423
p.P3115L	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.P3115L	201T	lung	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.P3115L	SCaBER	urinary_tract	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.P3115L	NCI-H2110	lung	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.P3115L	Hep_3B2_1-7	NS	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.R3113S	RKN	ovary	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.0556
p.G3128S	NCI-H510A	lung	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.6993
p.T3117S	NCI-H2452	pleura	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.1667
p.T3118P	KURAMOCHI	ovary	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.1944
p.E3132G	LS-411N	large_intestine	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.2222
p.S3127L	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.6556
p.S3136Y	KYSE-450	oesophagus	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.S3123R	SCaBER	urinary_tract	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	1566:1571	LTPASS	FBXW7	0.6595	More...
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	3123:3128	LTPASS	FBXW7	0.8291	More...
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	4206:4211	LTPASS	FBXW7	0.6169	More...
Q9UM11	Fizzy-related protein homolog	DEG_SCF_FBW7_1	31:36	LTPASS	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons