DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SCF_FBW7_1

Location: 4206:4211

E3 ligase: FBXW7

DEGRON score: 0.6169

ASA_SCORE: 84.5

COIL: 0.8867

CONS_SCORE: 0

DSS_SCORE: 0.6399

HELIX: 0.0197

FCONS_SCORE: 0

RIG_SCORE: 0.668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4214A	DO229348	LAML	ICGC	LTPASS	DEG_SCF_FBW7_1	0.25
p.T4214A	DO228974	LICA	ICGC	LTPASS	DEG_SCF_FBW7_1	0.25
p.P4198L	SIDM00857	Melanoma	GDSC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.P4198L	G-361	skin	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.1111
p.R4196S	SIDM00353	Other Sarcomas	GDSC	LTPASS	DEG_SCF_FBW7_1	0.0556
p.R4196S	RKN	ovary	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.0556
p.G4215A	IGR-37	skin	COSMIC	LTPASS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	1566:1571	LTPASS	FBXW7	0.6595	More...
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	3123:3128	LTPASS	FBXW7	0.8291	More...
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	4206:4211	LTPASS	FBXW7	0.6169	More...
Q9UM11	Fizzy-related protein homolog	DEG_SCF_FBW7_1	31:36	LTPASS	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons