DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SCF_FBW7_1

Location: 1566:1571

E3 ligase: FBXW7

DEGRON score: 0.6595

ASA_SCORE: 86.8167

COIL: 0.8788

CONS_SCORE: 0

DSS_SCORE: 0.6325

HELIX: 0.0182

FCONS_SCORE: 0

RIG_SCORE: 0.6776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1581I	DO228923	LICA	ICGC	LTPASS	DEG_SCF_FBW7_1	0.0556
p.T1581I	ACH-000467	Colon/Colorectal Cancer	CCLE	LTPASS	DEG_SCF_FBW7_1	0.0556
p.A1574T	DO228991	LICA	ICGC	LTPASS	DEG_SCF_FBW7_1	0.25
p.A1574T	DO229040	LICA	ICGC	LTPASS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	1566:1571	LTPASS	FBXW7	0.6595	More...
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	3123:3128	LTPASS	FBXW7	0.8291	More...
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	4206:4211	LTPASS	FBXW7	0.6169	More...
Q9UM11	Fizzy-related protein homolog	DEG_SCF_FBW7_1	31:36	LTPASS	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons