DegronMD

Uniprot ID: Q9UM11

Source protein: Fizzy-related protein homolog

Source gene: FZR1

Class: DEG_APCC_TPR_1

Location: 494:496

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9686

ASA_SCORE: 123.6333

COIL: 0.8817

CONS_SCORE: 0.5896

DSS_SCORE: 0.553

HELIX: 0.048

FCONS_SCORE: 1.5861

RIG_SCORE: 0.8839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L489H	TCGA-F4-6463	COAD	TCGA	RIR	DEG_APCC_TPR_1	0.1944
p.S487F	SIDM00121	T-Lymphoblastic Leukemia	GDSC	RIR	DEG_APCC_TPR_1	0.1389
p.S487F	ACH-001738	Leukemia	CCLE	RIR	DEG_APCC_TPR_1	0.1389
p.S487F	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	RIR	DEG_APCC_TPR_1	0.1389
p.S484F	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	RIR	DEG_APCC_TPR_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12996	Cleavage stimulation factor subunit 3	DEG_APCC_TPR_1	715:717	RIR	APC,CDC20,FZR1	0.9327	More...
Q9UM11	Fizzy-related protein homolog	DEG_APCC_TPR_1	494:496	RIR	APC,CDC20,FZR1	0.9686	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons