DegronMD

Uniprot ID: Q12996

Source protein: Cleavage stimulation factor subunit 3

Source gene: CSTF3

Class: DEG_APCC_TPR_1

Location: 715:717

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9327

ASA_SCORE: 161.5

COIL: 0.9093

CONS_SCORE: 0.2807

DSS_SCORE: 0.8928

HELIX: 0.0967

FCONS_SCORE: 0.9568

RIG_SCORE: 0.7691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R711Q	DO233272	GACA	ICGC	RIR	DEG_APCC_TPR_1	0.2222
p.D706V	SIDM02059	Colorectal Carcinoma	GDSC	RIR	DEG_APCC_TPR_1	0.0833
p.R717Q	SIDM01609	Endometrial Carcinoma	GDSC	RIR	DEG_APCC_TPR_1	0.7329
p.R717Q	ACH-000972	Endometrial/Uterine Cancer	CCLE	RIR	DEG_APCC_TPR_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12996	Cleavage stimulation factor subunit 3	DEG_APCC_TPR_1	715:717	RIR	APC,CDC20,FZR1	0.9327	More...
Q9UM11	Fizzy-related protein homolog	DEG_APCC_TPR_1	494:496	RIR	APC,CDC20,FZR1	0.9686	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons